urb1 URB1 ribosome biogenesis homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: urb1provided by ZNC
Official Full Name: URB1 ribosome biogenesis homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5181
See related: Ensembl:ENSDARG00000060308 AllianceGenome:ZFIN:ZDB-GENE-030131-5181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mp:zf637-1-000544
Summary: Acts upstream of or within digestive tract development and regulation of ribosome biogenesis. Predicted to be active in nucleolus. Is expressed in digestive system; embryonic structure; and head. Orthologous to human URB1 (URB1 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (5632521..5720646, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (5644670..5732795, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.
Title: Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.
Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish
Title: Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleolar pre-ribosomal-associated protein 1

Names: zf637-1-000544

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326445.1 → NP_001313374.1 nucleolar pre-ribosomal-associated protein 1

Status: VALIDATED

Source sequence(s)

BX088654, CR388135

UniProtKB/TrEMBL

A0A0R4ILM9, A0A8M1P7Y6

Related

ENSDARP00000135509.1, ENSDART00000158034.3

Conserved Domains (2) summary

pfam11707
Location:76 → 387

Npa1; Ribosome 60S biogenesis N-terminal

pfam16201
Location:1649 → 1838

NopRA1; Nucleolar pre-ribosomal-associated protein 1