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    CDA cytidine deaminase [ Homo sapiens (human) ]

    Gene ID: 978, updated on 5-Aug-2018

    Summary

    Official Symbol
    CDAprovided by HGNC
    Official Full Name
    cytidine deaminaseprovided by HGNC
    Primary source
    HGNC:HGNC:1712
    See related
    Ensembl:ENSG00000158825 MIM:123920; Vega:OTTHUMG00000002845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDD
    Summary
    This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 57.6), esophagus (RPKM 22.6) and 8 other tissues See more
    Orthologs

    Genomic context

    See CDA in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (20588951..20618908)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20915444..20945401)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 4 Neighboring gene family with sequence similarity 43 member B Neighboring gene microRNA 6084 Neighboring gene PTEN induced kinase 1 Neighboring gene PINK1 antisense RNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytidine deaminase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoside binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytidine deamination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pyrimidine nucleoside salvage TAS
    Traceable Author Statement
    more info
     
    pyrimidine-containing compound salvage NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cytidine deaminase
    Names
    cytidine aminohydrolase
    cytosine nucleoside deaminase
    small cytidine deaminase
    NP_001776.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001785.2NP_001776.1  cytidine deaminase

      See identical proteins and their annotated locations for NP_001776.1

      Status: REVIEWED

      Source sequence(s)
      BC048284, BC054036, CD675458
      Consensus CDS
      CCDS210.1
      UniProtKB/Swiss-Prot
      P32320
      Related
      ENSP00000364212.3, OTTHUMP00000002883, ENST00000375071.3, OTTHUMT00000007965
      Conserved Domains (1) summary
      TIGR01354
      Location:16142
      cyt_deam_tetra; cytidine deaminase, homotetrameric

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      20588951..20618908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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