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    Wwtr1 WW domain containing transcription regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 97064, updated on 15-Oct-2019

    Summary

    Official Symbol
    Wwtr1provided by MGI
    Official Full Name
    WW domain containing transcription regulator 1provided by MGI
    Primary source
    MGI:MGI:1917649
    See related
    Ensembl:ENSMUSG00000027803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taz; C78399; 2310058J06Rik; 2610021I22Rik
    Summary
    This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
    Annotation information
    Note: Wwtr1 (Gene ID: 97064) and Taz (Gene ID: 66826) loci share the Taz symbol/alias in common. [08 Feb 2019]
    Expression
    Broad expression in bladder adult (RPKM 25.1), lung adult (RPKM 24.7) and 26 other tissues See more
    Orthologs

    Genomic context

    See Wwtr1 in Genome Data Viewer
    Location:
    3; 3 D
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (57455644..57575910, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (57259566..57379832, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene transmembrane 4 superfamily member 4 Neighboring gene NEDD8-conjugating enzyme UBE2F pseudogene Neighboring gene predicted gene, 26671 Neighboring gene microRNA 6377 Neighboring gene predicted gene, 46805 Neighboring gene COMM domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    kidney morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of metanephric nephron tubule epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WW domain-containing transcription regulator protein 1
    Names
    transcriptional coactivator with PDZ-binding motif

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168281.1NP_001161753.1  WW domain-containing transcription regulator protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001161753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AK009983, AK142299, AK142720, AV026487, AW457051
      Consensus CDS
      CCDS50912.1
      UniProtKB/Swiss-Prot
      Q9EPK5
      Related
      ENSMUSP00000113040.1, ENSMUST00000120977.1
      Conserved Domains (1) summary
      smart00456
      Location:182213
      WW; Domain with 2 conserved Trp (W) residues
    2. NM_133784.3NP_598545.2  WW domain-containing transcription regulator protein 1 isoform 2

      See identical proteins and their annotated locations for NP_598545.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK009983, AK142299, AK142720, AV026487, AW457051, BY145519
      Consensus CDS
      CCDS38434.1
      UniProtKB/Swiss-Prot
      Q9EPK5
      Related
      ENSMUSP00000029380.7, ENSMUST00000029380.13
      Conserved Domains (1) summary
      smart00456
      Location:125156
      WW; Domain with 2 conserved Trp (W) residues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p6 C57BL/6J

      Range
      57455644..57575910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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