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    MRPL33 mitochondrial ribosomal protein L33 [ Homo sapiens (human) ]

    Gene ID: 9553, updated on 11-Mar-2018
    Official Symbol
    MRPL33provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L33provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000243147 MIM:610059; Vega:OTTHUMG00000097795
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L33mt; C2orf1; RPL33L; MRP-L33
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Ubiquitous expression in adrenal (RPKM 150.4), kidney (RPKM 51.5) and 23 other tissues See more
    Exon count:
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (27771717..27779741)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27994584..28002608)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374378 Neighboring gene long intergenic non-protein coding RNA 1460 Neighboring gene ribokinase Neighboring gene chromosome 12 open reading frame 10 pseudogene Neighboring gene BRE antisense RNA 1 Neighboring gene BRISC and BRCA1 A complex member 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    NHGRI GWAS Catalog

    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    NHGRI GWA Catalog
    • Mitochondrial translation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
    • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
    • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
    • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
      Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Ribosome, organism-specific biosystem (from KEGG)
      Ribosome, organism-specific biosystem
    • Ribosome, conserved biosystem (from KEGG)
      Ribosome, conserved biosystem
    Products Interactant Other Gene Complex Source Pubs Description


    Potential readthrough

    Included gene: BABAM2


    Clone Names

    • MGC13694, MGC23922, MGC111093

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    Process Evidence Code Pubs
    mitochondrial translational elongation TAS
    Traceable Author Statement
    more info
    mitochondrial translational termination TAS
    Traceable Author Statement
    more info
    Component Evidence Code Pubs
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    Preferred Names
    39S ribosomal protein L33, mitochondrial
    mitochondrial large ribosomal subunit protein bL33m

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004891.3NP_004882.1  39S ribosomal protein L33, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_004882.1

      Status: REVIEWED

      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AA836397, BC020834, BC090047
      Consensus CDS
      ENSP00000296102.3, OTTHUMP00000123443, ENST00000296102.7, OTTHUMT00000215049
      Conserved Domains (1) summary
      Ribosomal_L33; Ribosomal protein L33
    2. NM_145330.2NP_663303.1  39S ribosomal protein L33, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_663303.1

      Status: REVIEWED

      Transcript Variant: This variant (2) lacks an internal segment, compared to variant 1, that causes a frameshift. It is not known if a protein product is made from this variant.
      Source sequence(s)
      AA836397, BC090047
      Consensus CDS
      ENSP00000368988.3, OTTHUMP00000200849, ENST00000379666.7, OTTHUMT00000324563

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly


    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1


    1. NC_018913.2 Alternate CHM1_1.1

      GenBank, FASTA, Sequence Viewer (Graphics)
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