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    MED17 mediator complex subunit 17 [ Homo sapiens (human) ]

    Gene ID: 9440, updated on 10-Oct-2019

    Summary

    Official Symbol
    MED17provided by HGNC
    Official Full Name
    mediator complex subunit 17provided by HGNC
    Primary source
    HGNC:HGNC:2375
    See related
    Ensembl:ENSG00000042429 MIM:603810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRB4; CRSP6; CRSP77; DRIP80; TRAP80
    Summary
    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 8.7), ovary (RPKM 8.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See MED17 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (93784282..93814963)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93517405..93546496)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 40 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit D Neighboring gene chromosome 11 open reading frame 54 Neighboring gene Sharpr-MPRA regulatory region 5970 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene uncharacterized LOC101060084

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of mediator complex subunit 17 (MED17) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of MED17 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10812

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nuclear receptor transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear receptor transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vitamin D receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 17
    Names
    ARC77
    CRSP complex subunit 6
    activator-recruited cofactor 77 kDa component
    cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa
    epididymis secretory sperm binding protein
    thyroid hormone receptor-associated protein complex 80 kDa component
    transcriptional coactivator CRSP77
    vitamin D3 receptor-interacting protein complex 80 kDa component

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028028.1 RefSeqGene

      Range
      5044..35725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004268.5NP_004259.3  mediator of RNA polymerase II transcription subunit 17

      See identical proteins and their annotated locations for NP_004259.3

      Status: REVIEWED

      Source sequence(s)
      AK001674, AP001894, DA506467
      Consensus CDS
      CCDS8295.1
      UniProtKB/Swiss-Prot
      Q9NVC6
      Related
      ENSP00000251871.3, ENST00000251871.9
      Conserved Domains (1) summary
      pfam10156
      Location:125398
      Med17; Subunit 17 of Mediator complex

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      93784282..93814963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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