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    Cadm3 cell adhesion molecule 3 [ Mus musculus (house mouse) ]

    Gene ID: 94332, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cadm3provided by MGI
    Official Full Name
    cell adhesion molecule 3provided by MGI
    Primary source
    MGI:MGI:2137858
    See related
    Ensembl:ENSMUSG00000005338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BIgR; Necl1; Tsll1; Igsf4b; Necl-1; SynCAM3
    Expression
    Biased expression in cerebellum adult (RPKM 149.0), frontal lobe adult (RPKM 64.2) and 7 other tissues See more
    Orthologs

    Genomic context

    See Cadm3 in Genome Data Viewer
    Location:
    1; 1 H3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (173334254..173367695, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (175264385..175297826, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene mucosal pentraxin 2 Neighboring gene atypical chemokine receptor 1 (Duffy blood group) Neighboring gene absent in melanoma 2 Neighboring gene nuclear encoded tRNA arginine 5 (anticodon TCT) Neighboring gene interferon activated gene 206

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell adhesion molecule 3
    Names
    TSLC1-like protein 1
    immunoglobulin superfamily, member 4B
    nectin-like protein 1
    nectin-lke 1
    synaptic cell adhesion molecule 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053199.3NP_444429.1  cell adhesion molecule 3 precursor

      See identical proteins and their annotated locations for NP_444429.1

      Status: VALIDATED

      Source sequence(s)
      AK053077, BY289385
      Consensus CDS
      CCDS15528.1
      UniProtKB/Swiss-Prot
      Q99N28
      Related
      ENSMUSP00000106851.1, ENSMUST00000111220.7
      Conserved Domains (3) summary
      cd05882
      Location:30124
      Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
      cd07705
      Location:145227
      Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
      smart00410
      Location:237314
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      173334254..173367695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497060.3XP_006497123.2  cell adhesion molecule 3 isoform X1

      See identical proteins and their annotated locations for XP_006497123.2

      UniProtKB/TrEMBL
      K4DI58
      Related
      ENSMUSP00000005470.4, ENSMUST00000005470.4
      Conserved Domains (4) summary
      cd05882
      Location:64158
      Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
      cd07705
      Location:179261
      Ig2_Necl-1; Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))
      smart00410
      Location:271348
      IG_like; Immunoglobulin like
      pfam13895
      Location:269348
      Ig_2; Immunoglobulin domain
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