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    Mrpl43 mitochondrial ribosomal protein L43 [ Mus musculus (house mouse) ]

    Gene ID: 94067, updated on 4-Dec-2018

    Summary

    Official Symbol
    Mrpl43provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L43provided by MGI
    Primary source
    MGI:MGI:2137229
    See related
    Ensembl:ENSMUSG00000025208
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bMRP36a; 4930442D21Rik
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 56.9), colon adult (RPKM 56.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Mrpl43 in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (45005014..45006442, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45079504..45080932, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene RIKEN cDNA 4930414N06 gene Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
     
    translation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    39S ribosomal protein L43, mitochondrial
    Names
    L43mt
    MRP-L43
    mitochondrial ribosomal protein bMRP36a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053164.3NP_444394.1  39S ribosomal protein L43, mitochondrial

      See identical proteins and their annotated locations for NP_444394.1

      Status: REVIEWED

      Source sequence(s)
      AA253916, BC048733, BY251956
      Consensus CDS
      CCDS38000.1
      UniProtKB/TrEMBL
      Q5RL20
      Related
      ENSMUSP00000095322.2, ENSMUST00000097715.2
      Conserved Domains (1) summary
      smart00916
      Location:38107
      L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      45005014..45006442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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