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    CD27 CD27 molecule [ Homo sapiens (human) ]

    Gene ID: 939, updated on 8-Jul-2021


    Official Symbol
    CD27provided by HGNC
    Official Full Name
    CD27 moleculeprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000139193 MIM:186711
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T14; S152; Tp55; TNFRSF7; S152. LPFS2
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
    Broad expression in lymph node (RPKM 38.5), spleen (RPKM 21.6) and 14 other tissues See more
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    Genomic context

    See CD27 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6444867..6451718)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6554121..6560879)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 10 Neighboring gene CD27 antisense RNA 1 Neighboring gene signal recognition particle 14 pseudogene 1 Neighboring gene TAP binding protein like Neighboring gene vesicle associated membrane protein 1 Neighboring gene plakophilin 2 pseudogene 1

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD27 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD27molecule (TNFRSF7: tumor necrosis factor receptor superfamily, member 7) in human B cells PubMed
    env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp140 upregulates the expression of the B cell activation marker CD38 and the memory B cell marker CD27 PubMed
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed
    Tat tat HIV-1 Tat upregulates the expression of CD27 in stimulated CD8+T lymphocytes PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Clone Names

    • MGC20393

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    located_in integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    located_in plasma membrane TAS
    Traceable Author Statement
    more info

    General protein information

    Preferred Names
    CD27 antigen
    CD27L receptor
    T cell activation antigen S152
    T-cell activation antigen CD27
    tumor necrosis factor receptor superfamily, member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


    1. NG_031995.1 RefSeqGene

      GenBank, FASTA, Sequence Viewer (Graphics), LRG_357

    mRNA and Protein(s)

    1. NM_001242.5NP_001233.2  CD27 antigen precursor

      Status: REVIEWED

      Source sequence(s)
      Consensus CDS
      ENSP00000266557.3, ENST00000266557.4
      Conserved Domains (1) summary
      TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020232.1XP_016875721.1  CD27 antigen isoform X1

    2. XM_017020234.1XP_016875723.1  CD27 antigen isoform X3

    3. XM_017020233.2XP_016875722.1  CD27 antigen isoform X2

    4. XM_011521042.3XP_011519344.1  CD27 antigen isoform X4

      Conserved Domains (1) summary
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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