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    TRIP13 thyroid hormone receptor interactor 13 [ Homo sapiens (human) ]

    Gene ID: 9319, updated on 12-Aug-2018

    Summary

    Official Symbol
    TRIP13provided by HGNC
    Official Full Name
    thyroid hormone receptor interactor 13provided by HGNC
    Primary source
    HGNC:HGNC:12307
    See related
    Ensembl:ENSG00000071539 MIM:604507; Vega:OTTHUMG00000090349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MVA3; 16E1BP
    Summary
    This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues See more
    Orthologs

    Genomic context

    See TRIP13 in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (892854..919348)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (892764..918164)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene bromodomain containing 9 Neighboring gene uncharacterized LOC100506688 Neighboring gene naked cuticle homolog 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Mosaic variegated aneuploidy syndrome 3
    MedGen: C4539839 OMIM: 617598 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, thyroid hormone receptor interactor 13 (TRIP13), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coregulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    female meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    male meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    meiotic recombination checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptonemal complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    pachytene checkpoint protein 2 homolog
    Names
    16E1-BP
    HPV16 E1 protein binding protein
    SH3TC1/TRIP13 fusion
    TR-interacting protein 13
    TRIP-13
    human papillomavirus type 16 E1 protein-binding protein
    thyroid receptor-interacting protein 13

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166260.1NP_001159732.1  pachytene checkpoint protein 2 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122719, AK310376, BG722761, DB443523
      Conserved Domains (2) summary
      COG0464
      Location:136289
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:175285
      AAA; ATPase family associated with various cellular activities (AAA)
    2. NM_004237.3NP_004228.1  pachytene checkpoint protein 2 homolog isoform 1

      See identical proteins and their annotated locations for NP_004228.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC019294, BG722761, BM999741, DB443523
      Consensus CDS
      CCDS3858.1
      UniProtKB/Swiss-Prot
      Q15645
      Related
      ENSP00000166345.3, OTTHUMP00000115407, ENST00000166345.7, OTTHUMT00000206721
      Conserved Domains (1) summary
      COG0464
      Location:136360
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      892854..919348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514163.2XP_011512465.1  pachytene checkpoint protein 2 homolog isoform X1

      See identical proteins and their annotated locations for XP_011512465.1

      UniProtKB/Swiss-Prot
      Q15645
      Conserved Domains (1) summary
      COG0464
      Location:136360
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
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