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    UBE2Q2 ubiquitin conjugating enzyme E2 Q2 [ Homo sapiens (human) ]

    Gene ID: 92912, updated on 5-Sep-2021

    Summary

    Official Symbol
    UBE2Q2provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Q2provided by HGNC
    Primary source
    HGNC:HGNC:19248
    See related
    Ensembl:ENSG00000140367 MIM:612501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in thyroid (RPKM 12.2), prostate (RPKM 10.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UBE2Q2 in Genome Data Viewer
    Location:
    15q24.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75843343..75901078)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76135788..76193419)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 49 Neighboring gene Sharpr-MPRA regulatory region 8353 Neighboring gene RNA, 7SL, cytoplasmic 510, pseudogene Neighboring gene F-box protein 22 Neighboring gene neuregulin 4 Neighboring gene transmembrane protein 266 Neighboring gene uncharacterized LOC101929439

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    GeneReviews: Not available
    New loci associated with kidney function and chronic kidney disease.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp762C143

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 Q2
    Names
    E2 ubiquitin-conjugating enzyme Q2
    ubiquitin carrier protein Q2
    ubiquitin conjugating enzyme E2Q family member 2
    ubiquitin-protein ligase Q2
    NP_001138807.1
    NP_001271311.1
    NP_775740.1
    XP_005254844.1
    XP_005254845.1
    XP_006720833.1
    XP_011520530.1
    XP_016878215.1
    XP_016878216.1
    XP_016878217.1
    XP_024305875.1
    XP_024305876.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145335.1NP_001138807.1  ubiquitin-conjugating enzyme E2 Q2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA476260, AC027104, AK296234, BC017708
      Consensus CDS
      CCDS45309.1
      UniProtKB/Swiss-Prot
      Q8WVN8
      Related
      ENSP00000456229.1, ENST00000561851.5
      Conserved Domains (1) summary
      cd00195
      Location:190346
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001284382.2NP_001271311.1  ubiquitin-conjugating enzyme E2 Q2 isoform 3

      See identical proteins and their annotated locations for NP_001271311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC019294, AC027104
      Consensus CDS
      CCDS66839.1
      UniProtKB/Swiss-Prot
      Q8WVN8
      Related
      ENSP00000456324.1, ENST00000569423.5
      Conserved Domains (2) summary
      cd00195
      Location:171327
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:994
      RWD; RWD domain
    3. NM_173469.4NP_775740.1  ubiquitin-conjugating enzyme E2 Q2 isoform 1

      See identical proteins and their annotated locations for NP_775740.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC019294, AC027104
      Consensus CDS
      CCDS10286.1
      UniProtKB/Swiss-Prot
      Q8WVN8
      Related
      ENSP00000267938.4, ENST00000267938.9
      Conserved Domains (2) summary
      cd00195
      Location:206362
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:994
      RWD; RWD domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      75843343..75901078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254787.2XP_005254844.1  ubiquitin-conjugating enzyme E2 Q2 isoform X1

      Conserved Domains (2) summary
      cl00154
      Location:206314
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:994
      RWD; RWD domain
    2. XM_005254788.2XP_005254845.1  ubiquitin-conjugating enzyme E2 Q2 isoform X3

      Conserved Domains (2) summary
      cl00154
      Location:194283
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:994
      RWD; RWD domain
    3. XM_006720770.2XP_006720833.1  ubiquitin-conjugating enzyme E2 Q2 isoform X7

      Conserved Domains (1) summary
      cl02687
      Location:994
      RWD; RWD domain
    4. XM_017022727.2XP_016878216.1  ubiquitin-conjugating enzyme E2 Q2 isoform X5

    5. XM_017022728.2XP_016878217.1  ubiquitin-conjugating enzyme E2 Q2 isoform X6

    6. XM_024450107.1XP_024305875.1  ubiquitin-conjugating enzyme E2 Q2 isoform X2

      Conserved Domains (2) summary
      cl00154
      Location:206288
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      cl02687
      Location:994
      RWD; RWD domain
    7. XM_024450108.1XP_024305876.1  ubiquitin-conjugating enzyme E2 Q2 isoform X8

      Conserved Domains (1) summary
      cl02687
      Location:994
      RWD; RWD domain
    8. XM_011522228.2XP_011520530.1  ubiquitin-conjugating enzyme E2 Q2 isoform X9

      Conserved Domains (1) summary
      cl02687
      Location:994
      RWD; RWD domain
    9. XM_017022726.1XP_016878215.1  ubiquitin-conjugating enzyme E2 Q2 isoform X4

    RNA

    1. XR_002957691.1 RNA Sequence

    2. XR_001751420.2 RNA Sequence

    3. XR_002957692.1 RNA Sequence

    4. XR_001751421.2 RNA Sequence

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