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    MAP3K13 mitogen-activated protein kinase kinase kinase 13 [ Homo sapiens (human) ]

    Gene ID: 9175, updated on 5-Aug-2018

    Summary

    Official Symbol
    MAP3K13provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 13provided by HGNC
    Primary source
    HGNC:HGNC:6852
    See related
    Ensembl:ENSG00000073803 MIM:604915; Vega:OTTHUMG00000156673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LZK; MLK; MEKK13
    Summary
    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See MAP3K13 in Genome Data Viewer
    Location:
    3q27.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (185282938..185489094)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185000729..185206882)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 2 Neighboring gene microRNA 5588 Neighboring gene ribosomal protein L4 pseudogene 4 Neighboring gene uncharacterized LOC101929018 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene lipase H

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
      Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC133196

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    JUN kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    COLOCALIZES_WITH IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with IkappaB kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 13
    Names
    leucine zipper-bearing kinase
    mixed lineage kinase
    NP_001229243.1
    NP_001229246.1
    NP_004712.1
    XP_011511612.1
    XP_016862945.1
    XP_016862946.1
    XP_016862947.1
    XP_016862948.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242314.1NP_001229243.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

      See identical proteins and their annotated locations for NP_001229243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC099661, AK312714, BQ432918
      Consensus CDS
      CCDS3270.1
      UniProtKB/Swiss-Prot
      O43283
      Related
      ENSP00000399910.1, OTTHUMP00000210397, ENST00000424227.5, OTTHUMT00000345270
      Conserved Domains (2) summary
      smart00221
      Location:168402
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:174410
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    2. NM_001242317.1NP_001229246.1  mitogen-activated protein kinase kinase kinase 13 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC099661, AK297646, BQ432918
      Consensus CDS
      CCDS56298.1
      UniProtKB/Swiss-Prot
      O43283
      Related
      ENSP00000411483.1, OTTHUMP00000210398, ENST00000446828.5, OTTHUMT00000345271
      Conserved Domains (1) summary
      cl21453
      Location:13203
      PKc_like; Protein Kinases, catalytic domain
    3. NM_004721.4NP_004712.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

      See identical proteins and their annotated locations for NP_004712.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB001872, AC099661, AC132516
      Consensus CDS
      CCDS3270.1
      UniProtKB/Swiss-Prot
      O43283
      Related
      ENSP00000265026.3, OTTHUMP00000210395, ENST00000265026.7, OTTHUMT00000345268
      Conserved Domains (2) summary
      smart00221
      Location:168402
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:174410
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    RNA

    1. NR_038322.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks eleven exons and contains an alternate 3' exon, compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 3.
      Source sequence(s)
      AI690808, BC015996, BC036593, BQ432918
      Related
      ENST00000448876.5, OTTHUMT00000345272

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      185282938..185489094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007456.1XP_016862945.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

      UniProtKB/Swiss-Prot
      O43283
      Conserved Domains (2) summary
      smart00221
      Location:168402
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:174410
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    2. XM_017007458.1XP_016862947.1  mitogen-activated protein kinase kinase kinase 13 isoform X3

    3. XM_011513310.2XP_011511612.1  mitogen-activated protein kinase kinase kinase 13 isoform X1

      See identical proteins and their annotated locations for XP_011511612.1

      UniProtKB/Swiss-Prot
      O43283
      Conserved Domains (2) summary
      smart00221
      Location:168402
      STYKc; Protein kinase; unclassified specificity
      cd14059
      Location:174410
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    4. XM_017007457.1XP_016862946.1  mitogen-activated protein kinase kinase kinase 13 isoform X2

      Related
      ENSP00000409325.1, OTTHUMP00000210400, ENST00000443863.5, OTTHUMT00000345273
    5. XM_017007459.2XP_016862948.1  mitogen-activated protein kinase kinase kinase 13 isoform X3

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