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    SCRN2 secernin 2 [ Homo sapiens (human) ]

    Gene ID: 90507, updated on 8-Oct-2018

    Summary

    Official Symbol
    SCRN2provided by HGNC
    Official Full Name
    secernin 2provided by HGNC
    Primary source
    HGNC:HGNC:30381
    See related
    Ensembl:ENSG00000141295 MIM:614966; Vega:OTTHUMG00000178290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ses2
    Expression
    Ubiquitous expression in fat (RPKM 52.8), kidney (RPKM 36.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See SCRN2 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (47837681..47841333, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45915047..45918699, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 7 Neighboring gene mitochondrial ribosomal protein L10 Neighboring gene leucine rich repeat containing 46 Neighboring gene Sp6 transcription factor Neighboring gene uncharacterized LOC102724532

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    secernin-2
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145023.1NP_001138495.1  secernin-2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame segment in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC003665, AW452880, BC002980
      Consensus CDS
      CCDS45723.1
      UniProtKB/Swiss-Prot
      Q96FV2
      Related
      ENSP00000383935.3, OTTHUMP00000259042, ENST00000407215.7, OTTHUMT00000441382
      Conserved Domains (1) summary
      cl00467
      Location:21231
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    2. NM_138355.3NP_612364.2  secernin-2 isoform 1

      See identical proteins and their annotated locations for NP_612364.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC003665, AW452880, BC010408, CN480733
      Consensus CDS
      CCDS11519.1
      UniProtKB/Swiss-Prot
      Q96FV2
      Related
      ENSP00000290216.9, OTTHUMP00000259043, ENST00000290216.13, OTTHUMT00000441383
      Conserved Domains (1) summary
      cl00467
      Location:21231
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      47837681..47841333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025286.1XP_016880775.1  secernin-2 isoform X2

    2. XM_005257776.5XP_005257833.1  secernin-2 isoform X1

      See identical proteins and their annotated locations for XP_005257833.1

      UniProtKB/Swiss-Prot
      Q96FV2
      Related
      ENSP00000463411.1, OTTHUMP00000259044, ENST00000584123.5
      Conserved Domains (1) summary
      cl00467
      Location:21231
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    3. XM_024451019.1XP_024306787.1  secernin-2 isoform X3

    RNA

    1. XR_934593.1 RNA Sequence

      Related
      ENST00000581645.5, OTTHUMT00000441385
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