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    SLAMF9 SLAM family member 9 [ Homo sapiens (human) ]

    Gene ID: 89886, updated on 29-Mar-2018

    Summary

    Official Symbol
    SLAMF9provided by HGNC
    Official Full Name
    SLAM family member 9provided by HGNC
    Primary source
    HGNC:HGNC:18430
    See related
    Ensembl:ENSG00000162723 MIM:608589; Vega:OTTHUMG00000024074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD2F10; CD84H1; SF2001; CD2F-10; CD84-H1
    Summary
    This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
    Expression
    Biased expression in stomach (RPKM 3.8), small intestine (RPKM 2.6) and 7 other tissues See more
    Orthologs

    Genomic context

    See SLAMF9 in Genome Data Viewer
    Location:
    1q23.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (159951492..159984730, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159921282..159924044, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene transgelin 2 Neighboring gene immunoglobulin superfamily member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1 Neighboring gene ribosomal protein L27a pseudogene 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    General gene information

    Markers

    Homology

    Clone Names

    • MGC88194

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SLAM family member 9
    Names
    CD2 family member 10
    CD84 homolog 1
    cluster of differentiation 2 antigen family member 10
    cluster of differentiation 84 homolog 1
    signaling lymphocytic activation molecule family member 2001
    signaling lymphocytic activation molecule family member 9

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146172.1NP_001139644.1  SLAM family member 9 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL513485, AY034613, AY358801, CB528634
      Consensus CDS
      CCDS53392.1
      UniProtKB/Swiss-Prot
      Q96A28
      Related
      ENSP00000357071.3, OTTHUMP00000025750, ENST00000368092.7, OTTHUMT00000060631
      Conserved Domains (1) summary
      cd05775
      Location:33130
      Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    2. NM_001146173.1NP_001139645.1  SLAM family member 9 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AY034613, BC070213, CB528634
      UniProtKB/Swiss-Prot
      Q96A28
      UniProtKB/TrEMBL
      Q6NSE6
      Conserved Domains (1) summary
      cl11960
      Location:3386
      Ig; Immunoglobulin domain
    3. NM_033438.3NP_254273.2  SLAM family member 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_254273.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL513485, AY034613, CB528634
      Consensus CDS
      CCDS1191.1
      UniProtKB/Swiss-Prot
      Q96A28
      Related
      ENSP00000357072.3, OTTHUMP00000025749, ENST00000368093.3, OTTHUMT00000060630
      Conserved Domains (2) summary
      cd05775
      Location:33130
      Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
      pfam13927
      Location:135204
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      159951492..159984730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002756.1XP_016858245.1  SLAM family member 9 isoform X1

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