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    H2AC11 H2A clustered histone 11 [ Homo sapiens (human) ]

    Gene ID: 8969, updated on 5-Sep-2021

    Summary

    Official Symbol
    H2AC11provided by HGNC
    Official Full Name
    H2A clustered histone 11provided by HGNC
    Primary source
    HGNC:HGNC:4737
    See related
    Ensembl:ENSG00000196787 MIM:615012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2AG; H2A/p; H2AFP; H2A.1b; H2AC13; H2AC15; H2AC16; H2AC17; pH2A/f; HIST1H2AG
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H2AC11 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27133043..27133535)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27100822..27101314)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374995 Neighboring gene H2B clustered histone 11 Neighboring gene H2B clustered histone 12 Neighboring gene H4 clustered histone 9 Neighboring gene H2A clustered histone 12

    Genomic regions, transcripts, and products

    Phenotypes

    Associated conditions

    Description Tests
    Common variants on chromosome 6p22.1 are associated with schizophrenia.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H2A type 1
    Names
    H2A histone family, member P
    histone 1, H2ag
    histone H2A/p
    histone H2A/ptl
    histone cluster 1 H2A family member g
    histone cluster 1, H2ag

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021064.5NP_066408.1  histone H2A type 1

      See identical proteins and their annotated locations for NP_066408.1

      Status: REVIEWED

      Source sequence(s)
      AL021807
      Consensus CDS
      CCDS4619.1
      UniProtKB/Swiss-Prot
      P0C0S8
      UniProtKB/TrEMBL
      A4FTV9, B2R5B3
      Related
      ENSP00000352119.2, ENST00000359193.3
      Conserved Domains (1) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      27133043..27133535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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