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    CCK cholecystokinin [ Homo sapiens (human) ]

    Gene ID: 885, updated on 8-Jul-2021

    Summary

    Official Symbol
    CCKprovided by HGNC
    Official Full Name
    cholecystokininprovided by HGNC
    Primary source
    HGNC:HGNC:1569
    See related
    Ensembl:ENSG00000187094 MIM:118440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in duodenum (RPKM 21.7), brain (RPKM 20.3) and 2 other tissues See more
    Orthologs
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    Genomic context

    See CCK in Genome Data Viewer
    Location:
    3p22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (42257826..42266185, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42299318..42307677, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene trafficking kinesin protein 1 Neighboring gene RNA, U4 small nuclear 78, pseudogene Neighboring gene uncharacterized LOC105377048 Neighboring gene spalt like transcription factor 4 pseudogene 6 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
    GeneReviews: Not available
    EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117187

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neuropeptide hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables peptide hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in digestion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in eating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of appetite IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon initial segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cholecystokinin
    Names
    cholecystokinin triacontatriapeptide
    prepro-cholecystokinin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000729.6NP_000720.1  cholecystokinin preproprotein

      See identical proteins and their annotated locations for NP_000720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC018358, BC111026, BI756101, BM544754, CB154424, HY140623
      Consensus CDS
      CCDS2696.1
      UniProtKB/Swiss-Prot
      P06307
      UniProtKB/TrEMBL
      Q6FG82
      Related
      ENSP00000379472.2, ENST00000396169.7
      Conserved Domains (1) summary
      pfam00918
      Location:4115
      Gastrin; Gastrin/cholecystokinin family
    2. NM_001174138.3NP_001167609.1  cholecystokinin preproprotein

      See identical proteins and their annotated locations for NP_001167609.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC008283
      Consensus CDS
      CCDS2696.1
      UniProtKB/Swiss-Prot
      P06307
      UniProtKB/TrEMBL
      Q6FG82
      Related
      ENSP00000409124.1, ENST00000434608.1
      Conserved Domains (1) summary
      pfam00918
      Location:4115
      Gastrin; Gastrin/cholecystokinin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      42257826..42266185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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