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    NRP1 neuropilin 1 [ Homo sapiens (human) ]

    Gene ID: 8829, updated on 19-Sep-2021

    Summary

    Official Symbol
    NRP1provided by HGNC
    Official Full Name
    neuropilin 1provided by HGNC
    Primary source
    HGNC:HGNC:8004
    See related
    Ensembl:ENSG00000099250 MIM:602069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP1; NRP; BDCA4; CD304; VEGF165R
    Summary
    This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NRP1 in Genome Data Viewer
    Location:
    10p11.22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (33177493..33334667, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (33466421..33623595, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ITGB1 divergent transcript Neighboring gene ribosomal protein L7a pseudogene 53 Neighboring gene ITGB1 adjacent tumor promoting lncRNA Neighboring gene RNA, 7SL, cytoplasmic 398, pseudogene Neighboring gene uncharacterized LOC105376489 Neighboring gene long intergenic non-protein coding RNA 2628

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
    GeneReviews: Not available
    Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.
    GeneReviews: Not available
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp781F1414, DKFZp686A03134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables coreceptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cytokine binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables growth factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables semaphorin receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables vascular endothelial growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables vascular endothelial growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables vascular endothelial growth factor-activated receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in VEGF-activated neuropilin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in VEGF-activated neuropilin signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in VEGF-activated neuropilin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in angiogenesis involved in coronary vascular morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in artery morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in axon extension involved in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon guidance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis involved in innervation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in basal dendrite arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in basal dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in branching involved in blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in branchiomotor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to hepatocyte growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in coronary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dichotomous subdivision of terminal units involved in salivary gland branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal root ganglion morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial tip cell fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in facial nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in facioacoustic ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in motor neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neural crest cell migration involved in autonomic nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuropilin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in otic placode development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axon extension involved in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of Cdc42 protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in renal artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina vasculature morphogenesis in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in semaphorin-plexin signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sensory neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in substrate-dependent cell migration, cell extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sympathetic ganglion development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sympathetic neuron projection extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sympathetic neuron projection guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trigeminal ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trigeminal nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventral trunk neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vestibulocochlear nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neurofilament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of semaphorin receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in sorting endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    neuropilin-1
    Names
    transmembrane receptor
    vascular endothelial cell growth factor 165 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030328.1 RefSeqGene

      Range
      5001..162415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024628.3NP_001019799.2  neuropilin-1 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.
      Source sequence(s)
      AL121748, AL353600
      Consensus CDS
      CCDS31180.1
      Related
      ENSP00000363955.4, ENST00000374822.8
      Conserved Domains (2) summary
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. NM_001024629.3NP_001019800.2  neuropilin-1 isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.
      Source sequence(s)
      AL121748, AL353600
      Consensus CDS
      CCDS31179.1
      Related
      ENSP00000363954.5, ENST00000374821.9
      Conserved Domains (2) summary
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. NM_001244972.2NP_001231901.2  neuropilin-1 isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.
      Source sequence(s)
      AL121748, AL353600
      Conserved Domains (4) summary
      smart00137
      Location:638798
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:839917
      DUF3481; C-terminal domain of neuropilin glycoprotein
    4. NM_001244973.2NP_001231902.2  neuropilin-1 isoform e precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
      Source sequence(s)
      AL121748, AL353600
      Conserved Domains (4) summary
      smart00137
      Location:638797
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:838916
      DUF3481; C-terminal domain of neuropilin glycoprotein
    5. NM_001330068.2NP_001316997.2  neuropilin-1 isoform f precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.
      Source sequence(s)
      AL121748, AL353600
      Consensus CDS
      CCDS81448.1
      Related
      ENSP00000379317.1, ENST00000395995.5
      Conserved Domains (4) summary
      smart00137
      Location:645804
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:828906
      DUF3481; C-terminal domain of neuropilin glycoprotein
    6. NM_003873.7NP_003864.5  neuropilin-1 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
      Source sequence(s)
      AL121748, AL353600
      Consensus CDS
      CCDS7177.1
      Related
      ENSP00000364001.2, ENST00000374867.7
      Conserved Domains (4) summary
      smart00137
      Location:645804
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:845923
      DUF3481; C-terminal domain of neuropilin glycoprotein

    RNA

    1. NR_045259.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL121748, AL353600
      Related
      ENST00000374875.5

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      33177493..33334667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717525.2XP_006717588.1  neuropilin-1 isoform X5

      Conserved Domains (6) summary
      cd06263
      Location:615768
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:808885
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:610769
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_006717524.2XP_006717587.1  neuropilin-1 isoform X4

      Conserved Domains (6) summary
      cd06263
      Location:615769
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:809886
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:610770
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. XM_006717522.2XP_006717585.1  neuropilin-1 isoform X2

      Conserved Domains (6) summary
      cd06263
      Location:650804
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:827904
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645805
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. XM_006717521.2XP_006717584.1  neuropilin-1 isoform X1

      Conserved Domains (6) summary
      cd06263
      Location:650804
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:844921
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645805
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. XM_017016866.2XP_016872355.1  neuropilin-1 isoform X6

    6. XM_017016865.2XP_016872354.1  neuropilin-1 isoform X3

    7. XM_011519756.2XP_011518058.1  neuropilin-1 isoform X9

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    8. XM_011519755.3XP_011518057.1  neuropilin-1 isoform X8

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    9. XM_006717526.2XP_006717589.1  neuropilin-1 isoform X7

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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