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    RAB11A RAB11A, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 8766, updated on 9-Sep-2018

    Summary

    Official Symbol
    RAB11Aprovided by HGNC
    Official Full Name
    RAB11A, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9760
    See related
    Ensembl:ENSG00000103769 MIM:605570; Vega:OTTHUMG00000133162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YL8
    Summary
    The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
    Expression
    Ubiquitous expression in esophagus (RPKM 50.5), adrenal (RPKM 37.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See RAB11A in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (65869459..65891991)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66161629..66184329)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370866 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 44 Neighboring gene transfer RNA-Gln (CTG) 1-4 Neighboring gene multiple EGF like domains 11 Neighboring gene uncharacterized LOC105370867 Neighboring gene microRNA 4311

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of RAB11A, member RAS oncogene family (RAB11A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of RAB11A, member RAS oncogene family (RAB11A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB11A; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
    Nef nef HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments PubMed
    nef RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
    Pr55(Gag) gag Rab11a modulates intracellular Gag expression in human cells PubMed
    gag HIV-1 Gag and viral RNA preferentially co-localize with multivesicular bodies and Rab11a endosomes PubMed
    capsid gag Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation PubMed
    reverse transcriptase gag-pol The highest RT activity is found in Rab11a compartments and Rab7a compartments in nontreated cells after 7 and 14 days of HIV-1 challenge, respectively, suggesting that the virus is mainly located in these endosomal compartments PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
      Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
    • Aquaporin-mediated transport, organism-specific biosystem (from REACTOME)
      Aquaporin-mediated transport, organism-specific biosystemAquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. Each monomer contains a central channel formed in part by two asparagine-proline-alanine motifs (NPA boxes) tha...
    • Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 downstream pathway, organism-specific biosystem
      Arf6 downstream pathway
    • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
      Cargo trafficking to the periciliary membrane, organism-specific biosystemProteomic studies suggest that the cilium is home to approximately a thousand proteins, and has a unique protein and lipid make up relative to the bulk cytoplasm and plasma membrane (Pazour et al, 20...
    • Cilium Assembly, organism-specific biosystem (from REACTOME)
      Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
    • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
      RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemRab GTPases are peripheral membrane proteins involved in membrane trafficking. Often through their indirect interactions with coat components, motors, tethering factors and SNAREs, the Rab GTPases se...
    • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Thromboxane A2 receptor signaling, organism-specific biosystem
      Thromboxane A2 receptor signaling
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Vasopressin regulates renal water homeostasis via Aquaporins, organism-specific biosystem (from REACTOME)
      Vasopressin regulates renal water homeostasis via Aquaporins, organism-specific biosystemIn the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate d...
    • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
      Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • VxPx cargo-targeting to cilium, organism-specific biosystem (from REACTOME)
      VxPx cargo-targeting to cilium, organism-specific biosystemA number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC1490

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin V binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    syntaxin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ciliary basal body-plasma membrane docking TAS
    Traceable Author Statement
    more info
     
    establishment of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    melanosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    melanosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multivesicular body assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane to endosome transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of multivesicular body size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal water homeostasis TAS
    Traceable Author Statement
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle-mediated transport in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus HDA PubMed 
    Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule organizing center IDA
    Inferred from Direct Assay
    more info
     
    multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic recycling endosome EXP
    Inferred from Experiment
    more info
    PubMed 
    postsynaptic recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    recycling endosome membrane TAS
    Traceable Author Statement
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-11A
    Names
    RAB 11A, member oncogene family
    rab-11

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206836.1NP_001193765.1  ras-related protein Rab-11A isoform 2

      See identical proteins and their annotated locations for NP_001193765.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC084854, AK300008, BC013348, BC047114, DC300743
      Consensus CDS
      CCDS58373.1
      UniProtKB/Swiss-Prot
      P62491
      Related
      ENSP00000456420.1, OTTHUMP00000249339, ENST00000569896.1, OTTHUMT00000420494
      Conserved Domains (1) summary
      cd01868
      Location:9146
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
    2. NM_004663.4NP_004654.1  ras-related protein Rab-11A isoform 1

      See identical proteins and their annotated locations for NP_004654.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC084854, BC013348, BC047114, DC300743
      Consensus CDS
      CCDS10212.1
      UniProtKB/Swiss-Prot
      P62491
      UniProtKB/TrEMBL
      A0A024R5Z8
      Related
      ENSP00000261890.2, OTTHUMP00000164214, ENST00000261890.6, OTTHUMT00000256864
      Conserved Domains (1) summary
      cd01868
      Location:9173
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

      Range
      65869459..65891991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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