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    ASMTL acetylserotonin O-methyltransferase like [ Homo sapiens (human) ]

    Gene ID: 8623, updated on 11-Jun-2021

    Summary

    Official Symbol
    ASMTLprovided by HGNC
    Official Full Name
    acetylserotonin O-methyltransferase likeprovided by HGNC
    Primary source
    HGNC:HGNC:751
    See related
    Ensembl:ENSG00000169093 MIM:300162; MIM:400011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASTML; ASMTLX; ASMTLY
    Summary
    The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 11.8), prostate (RPKM 10.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ASMTL in Genome Data Viewer
    Location:
    X;Y
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (1403139..1453794, complement)
    109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (1403139..1453794, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1522032..1572649, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1472032..1522649, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373102 Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene P2Y receptor family member 8 Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373102 Neighboring gene long intergenic non-protein coding RNA 106 Neighboring gene ASMTL antisense RNA 1 Neighboring gene P2Y receptor family member 8 Neighboring gene A-kinase anchoring protein 17A Neighboring gene acetylserotonin O-methyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables UTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dTTP diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables nucleoside-triphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein
    Names
    N-acetylserotonin O-methyltransferase-like protein
    acetylserotonin N-methyltransferase-like
    NP_001166944.1
    NP_001166945.1
    NP_004183.2
    XP_005274491.1
    XP_005274840.1
    XP_011543940.1
    XP_011544487.1
    XP_016885408.1
    XP_016885573.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016772.1 RefSeqGene

      Range
      5854..55624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173473.2NP_001166944.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK225770, AK301844, BM129217, BU688748, DA904467
      Consensus CDS
      CCDS55362.1
      UniProtKB/Swiss-Prot
      O95671
      Related
      ENSP00000446410.1, ENST00000534940.6
      Conserved Domains (3) summary
      cd00555
      Location:1150
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:229313
      Dimerisation2; Dimerization domain
      cl17173
      Location:330546
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001173474.2NP_001166945.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 3

      See identical proteins and their annotated locations for NP_001166945.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK090498, AK225770, AK301844, BM129217, BU688748
      Consensus CDS
      CCDS55363.1
      UniProtKB/Swiss-Prot
      O95671
      Related
      ENSP00000370734.4, ENST00000381333.9
      Conserved Domains (3) summary
      cd00555
      Location:15192
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:271355
      Dimerisation2; Dimerization domain
      cl17173
      Location:372588
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_004192.4NP_004183.2  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 1

      See identical proteins and their annotated locations for NP_004183.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)
      Source sequence(s)
      AK001090, AK225770, AK301844, BM129217, BU688748, DA005122
      Consensus CDS
      CCDS43917.1
      UniProtKB/Swiss-Prot
      O95671
      UniProtKB/TrEMBL
      B3KM43
      Related
      ENSP00000370718.3, ENST00000381317.9
      Conserved Domains (3) summary
      cd00555
      Location:15208
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:287371
      dimerization2; dimerization domain
      cl17173
      Location:388599
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      1403139..1453794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274434.3XP_005274491.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X1

      See identical proteins and their annotated locations for XP_005274491.1

      UniProtKB/Swiss-Prot
      O95671
      Conserved Domains (3) summary
      cd00555
      Location:15208
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:287371
      dimerization2; dimerization domain
      cl17173
      Location:388599
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_017029919.2XP_016885408.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X3

      Conserved Domains (3) summary
      pfam16864
      Location:178262
      dimerization2; dimerization domain
      cl00276
      Location:199
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...
      cl17173
      Location:279490
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_011546185.2XP_011544487.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X2

      See identical proteins and their annotated locations for XP_011544487.1

      Conserved Domains (3) summary
      cd00555
      Location:9125
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:204288
      dimerization2; dimerization domain
      cl17173
      Location:305516
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

      Range
      1403139..1453794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274783.3XP_005274840.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X1

      See identical proteins and their annotated locations for XP_005274840.1

      UniProtKB/Swiss-Prot
      O95671
      Conserved Domains (3) summary
      cd00555
      Location:15208
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:287371
      dimerization2; dimerization domain
      cl17173
      Location:388599
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_017030084.2XP_016885573.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X3

      Conserved Domains (3) summary
      pfam16864
      Location:178262
      dimerization2; dimerization domain
      cl00276
      Location:199
      Maf_Ham1; Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, ...
      cl17173
      Location:279490
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_011545638.2XP_011543940.1  probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform X2

      See identical proteins and their annotated locations for XP_011543940.1

      Conserved Domains (3) summary
      cd00555
      Location:9125
      Maf; Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or ...
      pfam16864
      Location:204288
      dimerization2; dimerization domain
      cl17173
      Location:305516
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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