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    AGPS alkylglycerone phosphate synthase [ Homo sapiens (human) ]

    Gene ID: 8540, updated on 12-Aug-2018

    Summary

    Official Symbol
    AGPSprovided by HGNC
    Official Full Name
    alkylglycerone phosphate synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:327
    See related
    Ensembl:ENSG00000018510 MIM:603051; Vega:OTTHUMG00000132530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADAS; ADPS; RCDP3; ADAP-S; ADHAPS; ALDHPSY
    Summary
    This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 7.8), endometrium (RPKM 6.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See AGPS in Genome Data Viewer
    Location:
    2q31.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (177392743..177543836)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178257471..178408564)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene nuclear factor, erythroid 2 like 2 Neighboring gene microRNA 3128 Neighboring gene uncharacterized LOC100130691 Neighboring gene microRNA 6512 Neighboring gene uncharacterized LOC105373762 Neighboring gene tetratricopeptide repeat domain 30B Neighboring gene tetratricopeptide repeat domain 30A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with alkylglycerone phosphate synthase (AGPS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    capsid gag The interaction of HIV-1 CA with human cellular alkylglycerone phosphate synthase protein (AGPS) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Ether lipid metabolism, organism-specific biosystem (from KEGG)
      Ether lipid metabolism, organism-specific biosystem
      Ether lipid metabolism
    • Ether lipid metabolism, conserved biosystem (from KEGG)
      Ether lipid metabolism, conserved biosystem
      Ether lipid metabolism
    • Glycerophospholipid Biosynthetic Pathway, organism-specific biosystem (from WikiPathways)
      Glycerophospholipid Biosynthetic Pathway, organism-specific biosystemGlycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty am...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Peroxisomal lipid metabolism, organism-specific biosystem (from REACTOME)
      Peroxisomal lipid metabolism, organism-specific biosystemIn humans, the catabolism of phytanate, pristanate, and very long chain fatty acids as well as the first four steps of the biosynthesis of plasmalogens are catalyzed by peroxisomal enzymes. Defects i...
    • Peroxisome, organism-specific biosystem (from KEGG)
      Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Peroxisome, conserved biosystem (from KEGG)
      Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Plasmalogen biosynthesis, organism-specific biosystem (from REACTOME)
      Plasmalogen biosynthesis, organism-specific biosystem1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organell...
    • Triacylglyceride Synthesis, organism-specific biosystem (from WikiPathways)
      Triacylglyceride Synthesis, organism-specific biosystem
      Triacylglyceride Synthesis

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ99755, DKFZp762O2215

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    alkylglycerone-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ether lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    ether lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ether lipid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    protein targeting to peroxisome TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane HDA PubMed 
    mitochondrion HDA PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    peroxisomal membrane HDA PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alkyldihydroxyacetonephosphate synthase, peroxisomal
    Names
    aging-associated gene 5 protein
    aging-associated protein 5
    alkyl-DHAP synthase
    NP_003650.1
    XP_011510343.1
    XP_011510344.1
    XP_011510345.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008968.1 RefSeqGene

      Range
      5001..156094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003659.3NP_003650.1  alkyldihydroxyacetonephosphate synthase, peroxisomal precursor

      See identical proteins and their annotated locations for NP_003650.1

      Status: REVIEWED

      Source sequence(s)
      AA832354, AC073834, AK314259, DC402978
      Consensus CDS
      CCDS2275.1
      UniProtKB/Swiss-Prot
      O00116
      Related
      ENSP00000264167.4, OTTHUMP00000163353, ENST00000264167.8, OTTHUMT00000255730
      Conserved Domains (3) summary
      COG0277
      Location:200652
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:206347
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:385657
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      177392743..177543836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512041.2XP_011510343.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

      See identical proteins and their annotated locations for XP_011510343.1

      UniProtKB/TrEMBL
      B7Z3Q4
      Related
      ENSP00000490844.1, OTTHUMP00000281753, ENST00000637633.1, OTTHUMT00000489070
      Conserved Domains (1) summary
      COG0277
      Location:110562
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    2. XM_011512042.1XP_011510344.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X1

      See identical proteins and their annotated locations for XP_011510344.1

      UniProtKB/TrEMBL
      B7Z3Q4
      Conserved Domains (1) summary
      COG0277
      Location:110562
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    3. XM_011512043.2XP_011510345.1  alkyldihydroxyacetonephosphate synthase, peroxisomal isoform X2

      Conserved Domains (3) summary
      COG0277
      Location:10407
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:11102
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:140412
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RNA

    1. XR_001739007.2 RNA Sequence

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