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    ADGRE3 adhesion G protein-coupled receptor E3 [ Homo sapiens (human) ]

    Gene ID: 84658, updated on 12-Aug-2018

    Summary

    Official Symbol
    ADGRE3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor E3provided by HGNC
    Primary source
    HGNC:HGNC:23647
    See related
    Ensembl:ENSG00000131355 MIM:606101; Vega:OTTHUMG00000183406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMR3
    Summary
    This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more
    Orthologs

    Genomic context

    See ADGRE3 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (14600175..14674918, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14730051..14785730, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene C-type lectin domain containing 17A Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene uncharacterized LOC107985308 Neighboring gene zinc finger protein 333 Neighboring gene adhesion G protein-coupled receptor E2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
      Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor E3
    Names
    EGF-like module receptor 3
    EGF-like module-containing mucin-like hormone receptor-like 3
    egf-like module containing, mucin-like, hormone receptor-like 3
    egf-like module-containing mucin-like receptor 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289158.1NP_001276087.1  adhesion G protein-coupled receptor E3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AF239764, AK298653, AL832663, AY358817, BC128053
      Consensus CDS
      CCDS74297.1
      UniProtKB/Swiss-Prot
      Q9BY15
      UniProtKB/TrEMBL
      A1L1B9, B7Z5A1
      Related
      ENSP00000340758.4, ENST00000344373.8
      Conserved Domains (2) summary
      pfam01825
      Location:252292
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:301542
      7tm_4; Olfactory receptor
    2. NM_001289159.1NP_001276088.1  adhesion G protein-coupled receptor E3 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AF239764, AK298653, AL832663, BC128053
      Consensus CDS
      CCDS74296.1
      UniProtKB/Swiss-Prot
      Q9BY15
      UniProtKB/TrEMBL
      A1L1B9, B7Z5A1, E7EW83
      Related
      ENSP00000396208.2, OTTHUMP00000271611, ENST00000443157.6, OTTHUMT00000466486
      Conserved Domains (2) summary
      pfam01825
      Location:178218
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:227468
      7tm_4; Olfactory receptor
    3. NM_032571.4NP_115960.2  adhesion G protein-coupled receptor E3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_115960.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF239764, AK298653, AL832663, BC121130, BC128053
      Consensus CDS
      CCDS12315.1
      UniProtKB/Swiss-Prot
      Q9BY15
      UniProtKB/TrEMBL
      A1L1B9, B7Z5A1, Q0IJ53
      Related
      ENSP00000253673.4, OTTHUMP00000271613, ENST00000253673.5, OTTHUMT00000466488
      Conserved Domains (3) summary
      cd00054
      Location:67104
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01825
      Location:304344
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:353594
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      14600175..14674918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528374.2XP_011526676.1  adhesion G protein-coupled receptor E3 isoform X1

      Conserved Domains (3) summary
      cd00054
      Location:5087
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01825
      Location:287327
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:336577
      7tm_4; Olfactory receptor
    2. XM_017027383.1XP_016882872.1  adhesion G protein-coupled receptor E3 isoform X2

      UniProtKB/TrEMBL
      M0R1G2
      Related
      ENSP00000471853.1, OTTHUMP00000271612, ENST00000599900.5, OTTHUMT00000466487

    RNA

    1. XR_001753772.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152939.1: Suppressed sequence

      Description
      NM_152939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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