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    ST6GAL2 ST6 beta-galactoside alpha-2,6-sialyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 84620, updated on 21-Dec-2019

    Summary

    Official Symbol
    ST6GAL2provided by HGNC
    Official Full Name
    ST6 beta-galactoside alpha-2,6-sialyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:10861
    See related
    Ensembl:ENSG00000144057 MIM:608472
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIAT2; ST6GalII
    Summary
    This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
    Expression
    Biased expression in thyroid (RPKM 11.0), brain (RPKM 3.9) and 3 other tissues See more
    Orthologs

    Genomic context

    See ST6GAL2 in Genome Data Viewer
    Location:
    2q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (106801600..106887410, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (107418056..107503563, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724744 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 12 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 5 Neighboring gene uncharacterized LOC105373535

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ30711, FLJ37730, FLJ38334, KIAA1877

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-galactoside alpha-2,6-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    oligosaccharide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    sialylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 2
    Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
    ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
    alpha 2,6-ST 2
    beta-galactoside alpha-2,6-sialyltransferase II
    sialyltransferase 2 (monosialoganglioside sialyltransferase)
    NP_001135823.1
    NP_001135824.1
    NP_001309291.1
    NP_115917.1
    XP_006712865.1
    XP_011510301.1
    XP_011510302.1
    XP_011510303.1
    XP_016860599.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031986.1 RefSeqGene

      Range
      4999..90508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142351.2NP_001135823.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_001135823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AB058780, AB059555, AC005040, AC108049, BQ016989, CN365495
      Consensus CDS
      CCDS2073.1
      UniProtKB/Swiss-Prot
      Q96JF0
      Related
      ENSP00000386942.3, ENST00000409382.7
      Conserved Domains (1) summary
      pfam00777
      Location:278511
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. NM_001142352.2NP_001135824.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform b

      See identical proteins and their annotated locations for NP_001135824.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC005040, AK307784, BC008680, DA176100
      Consensus CDS
      CCDS46380.1
      UniProtKB/Swiss-Prot
      Q96JF0
      Related
      ENSP00000387332.3, ENST00000409087.3
      Conserved Domains (1) summary
      pfam00777
      Location:278439
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    3. NM_001322362.2NP_001309291.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC005040, AC016994, AC108049, R61253
      Consensus CDS
      CCDS2073.1
      UniProtKB/Swiss-Prot
      Q96JF0
      Conserved Domains (1) summary
      pfam00777
      Location:278511
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    4. NM_032528.3NP_115917.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_115917.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AB059555, AC005040, AC108049, BQ016989, CN365495, DA176100
      Consensus CDS
      CCDS2073.1
      UniProtKB/Swiss-Prot
      Q96JF0
      Related
      ENSP00000355273.4, ENST00000361686.8
      Conserved Domains (1) summary
      pfam00777
      Location:278511
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. NR_136313.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005040, AC016994, AC108049, R61253

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      106801600..106887410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511999.2XP_011510301.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_011510301.1

      UniProtKB/Swiss-Prot
      Q96JF0
      Conserved Domains (1) summary
      pfam00777
      Location:278511
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    2. XM_006712802.1XP_006712865.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006712865.1

      UniProtKB/Swiss-Prot
      Q96JF0
      Conserved Domains (1) summary
      pfam00777
      Location:278511
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    3. XM_011512001.2XP_011510303.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X3

      See identical proteins and their annotated locations for XP_011510303.1

      UniProtKB/Swiss-Prot
      Q96JF0
      Conserved Domains (1) summary
      pfam00777
      Location:278439
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    4. XM_017005110.1XP_016860599.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X4

    5. XM_011512000.2XP_011510302.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X2

      Conserved Domains (1) summary
      pfam00777
      Location:278442
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. XR_923046.2 RNA Sequence

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