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    DOC2B double C2 domain beta [ Homo sapiens (human) ]

    Gene ID: 8447, updated on 17-Jun-2019

    Summary

    Official Symbol
    DOC2Bprovided by HGNC
    Official Full Name
    double C2 domain betaprovided by HGNC
    Primary source
    HGNC:HGNC:2986
    See related
    Ensembl:ENSG00000272636 MIM:604568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOC2BL
    Summary
    There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 3.2), bone marrow (RPKM 2.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See DOC2B in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (142789..181650, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6009..31421, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929823 Neighboring gene uncharacterized LOC101929828 Neighboring gene secretoglobin family 1C member 2 Neighboring gene long intergenic non-protein coding RNA 2091 Neighboring gene rabphilin 3A like (without C2 domains) Neighboring gene uncharacterized LOC100506388

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    calcium ion-regulated exocytosis of neurotransmitter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of calcium ion-dependent exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spontaneous neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    double C2-like domain-containing protein beta
    Names
    doc2-beta
    double C2-like domains, beta

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021143.2 RefSeqGene

      Range
      5001..39824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003585.5NP_003576.2  double C2-like domain-containing protein beta

      See identical proteins and their annotated locations for NP_003576.2

      Status: REVIEWED

      Source sequence(s)
      AC108004, AC240565, AI478508, D70830
      Consensus CDS
      CCDS73934.1
      UniProtKB/Swiss-Prot
      Q14184
      UniProtKB/TrEMBL
      A0A087WZX8
      Related
      ENSP00000482950.1, ENST00000613549.3
      Conserved Domains (2) summary
      cd04035
      Location:127250
      C2A_Rabphilin_Doc2; C2 domain first repeat present in Rabphilin and Double C2 domain
      cd08384
      Location:269401
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      142789..181650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535363.3XP_011533665.1  double C2-like domain-containing protein beta isoform X1

      Conserved Domains (2) summary
      cd08384
      Location:244376
      C2B_Rabphilin_Doc2; C2 domain second repeat present in Rabphilin and Double C2 domain
      cl14603
      Location:127225
      C2; C2 domain
    2. XM_017025227.1XP_016880716.1  double C2-like domain-containing protein beta isoform X2

    RNA

    1. XR_001752664.1 RNA Sequence

    2. XR_942189.2 RNA Sequence

    3. XR_942190.2 RNA Sequence

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NW_003315952.3 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      82789..120582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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