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    PRAM1 PML-RARA regulated adaptor molecule 1 [ Homo sapiens (human) ]

    Gene ID: 84106, updated on 2-Oct-2018

    Summary

    Official Symbol
    PRAM1provided by HGNC
    Official Full Name
    PML-RARA regulated adaptor molecule 1provided by HGNC
    Primary source
    HGNC:HGNC:30091
    See related
    Ensembl:ENSG00000133246 MIM:606466; Vega:OTTHUMG00000167924
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRAM-1; PML-RAR
    Summary
    The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues See more
    Orthologs

    Genomic context

    See PRAM1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (8490055..8502654, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8554940..8567538, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene zinc finger protein 414 Neighboring gene myosin IF

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC39864

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of neutrophil degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    PML-RARA-regulated adapter molecule 1
    Names
    PML-RARA target gene encoding an Adaptor Molecule-1
    PRAM

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032152.4NP_115528.4  PML-RARA-regulated adapter molecule 1

      See identical proteins and their annotated locations for NP_115528.4

      Status: REVIEWED

      Source sequence(s)
      AC092298, AJ272324, AK308227, BC028012, DA350460
      Consensus CDS
      CCDS45954.2
      UniProtKB/Swiss-Prot
      Q96QH2
      Related
      ENSP00000408342.2, OTTHUMP00000237315, ENST00000423345.4, OTTHUMT00000397040
      Conserved Domains (2) summary
      pfam14603
      Location:577655
      hSH3; Helically-extended SH3 domain
      cl26464
      Location:56412
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

      Range
      8490055..8502654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272502.2XP_005272559.1  PML-RARA-regulated adapter molecule 1 isoform X2

      Conserved Domains (1) summary
      pfam14603
      Location:582655
      hSH3; Helically-extended SH3 domain
    2. XM_011528352.2XP_011526654.1  PML-RARA-regulated adapter molecule 1 isoform X1

      Conserved Domains (1) summary
      pfam14603
      Location:584657
      hSH3; Helically-extended SH3 domain
    3. XM_011528353.2XP_011526655.1  PML-RARA-regulated adapter molecule 1 isoform X3

      Conserved Domains (1) summary
      pfam14603
      Location:584665
      hSH3; Helically-extended SH3 domain
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