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    NCALD neurocalcin delta [ Homo sapiens (human) ]

    Gene ID: 83988, updated on 9-Aug-2021

    Summary

    Official Symbol
    NCALDprovided by HGNC
    Official Full Name
    neurocalcin deltaprovided by HGNC
    Primary source
    HGNC:HGNC:7655
    See related
    Ensembl:ENSG00000104490 MIM:606722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Broad expression in brain (RPKM 22.6), salivary gland (RPKM 11.3) and 20 other tissues See more
    Orthologs
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    Genomic context

    See NCALD in Genome Data Viewer
    Location:
    8q22.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (101686542..102124907, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (102698770..103137135, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SAP domain containing ribonucleoprotein pseudogene Neighboring gene grainyhead like transcription factor 2 Neighboring gene probable ribosome biogenesis protein RLP24 pseudogene Neighboring gene PDCL3 pseudogene 2 Neighboring gene uncharacterized LOC107986963 Neighboring gene uncharacterized LOC104054148 Neighboring gene 6.8 kDa mitochondrial proteolipid-like Neighboring gene microRNA 5680

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Common genetic variation and performance on standardized cognitive tests.
    GeneReviews: Not available
    Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
    GeneReviews: Not available
    Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC33870, MGC74858

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of clathrin coat of trans-Golgi network vesicle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040624.2NP_001035714.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035714.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) includes five untranslated exons at the 5' end.
      Source sequence(s)
      AP000426, AP001206, AP001328, AP001575
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    2. NM_001040625.2NP_001035715.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035715.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1.
      Source sequence(s)
      AP000426, BC063428, BM681731
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Related
      ENSP00000428105.1, ENST00000521599.5
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    3. NM_001040626.2NP_001035716.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035716.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR compared to variant 1.
      Source sequence(s)
      AP000426, AP001206, AP001328, AP001575
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Related
      ENSP00000310587.3, ENST00000311028.4
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    4. NM_001040627.2NP_001035717.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035717.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two exons in the 5' UTR compared to variant 1.
      Source sequence(s)
      AP000426, BC036098, BC063428, BM681731, DA417037
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    5. NM_001040628.2NP_001035718.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1.
      Source sequence(s)
      AP000426, BC063428, BM681731, DA417037, DA776593
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    6. NM_001040629.2NP_001035719.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035719.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1.
      Source sequence(s)
      AP000426, BC063428, BM681731, DA417037, DA779293
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    7. NM_001040630.2NP_001035720.1  neurocalcin-delta

      See identical proteins and their annotated locations for NP_001035720.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1.
      Source sequence(s)
      AP000426, BC063428, BM681731, DA215759, DB284042
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Related
      ENSP00000379256.1, ENST00000395923.5
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    8. NM_032041.3NP_114430.2  neurocalcin-delta

      See identical proteins and their annotated locations for NP_114430.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1.
      Source sequence(s)
      AL136612, AP000426, BC063428, BM681731, DA211806
      Consensus CDS
      CCDS6292.1
      UniProtKB/Swiss-Prot
      P61601
      UniProtKB/TrEMBL
      B2RB70
      Related
      ENSP00000220931.6, ENST00000220931.11
      Conserved Domains (1) summary
      COG5126
      Location:14179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      101686542..102124907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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