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    STN1 Nucleic acid-binding, OB-fold-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837223, updated on 11-Oct-2018

    Summary

    Gene symbol
    STN1
    Gene description
    Nucleic acid-binding, OB-fold-like protein
    Primary source
    Araport:AT1G07130
    Locus tag
    AT1G07130
    Gene type
    protein coding
    RNA name
    Nucleic acid-binding, OB-fold-like protein
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSTN1; F10K1.17; F10K1_17
    Summary
    Encodes a protein with similarity to yeast STN1, an OB fold protein involved in protecting yeast telomeres. In Arabidopsis, loss of STN1 function mutations exhibit gross morphological abnormalities and defects in telomere architecture and maintenance. STN1 likely plays a role in telomere end capping.

    Genomic context

    See STN1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (2187776..2188733)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CHUP1-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glycine-rich protein Neighboring gene Pleckstrin homology (PH) domain superfamily protein

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_100586.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telomere maintenance via telomere lengthening IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    CST complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    Nucleic acid-binding, OB-fold-like protein
    NP_563781.1
    • STN1; FUNCTIONS IN: nucleic acid binding; INVOLVED IN: telomere capping; LOCATED IN: nuclear chromosome, telomeric region; EXPRESSED IN: root, seed; EXPRESSED DURING: E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365); Has 110 Blast hits to 110 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 57; Fungi - 2; Plants - 47; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2187776..2188733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100586.2NP_563781.1  Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563781.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LMK5
      UniProtKB/TrEMBL
      A0A178W9Z5
      Conserved Domains (1) summary
      cd04483
      Location:42133
      hOBFC1_like; hOBFC1_like: A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which ...
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