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    Akr1c6 aldo-keto reductase family 1, member C6 [ Mus musculus (house mouse) ]

    Gene ID: 83702, updated on 31-Jan-2019

    Summary

    Official Symbol
    Akr1c6provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member C6provided by MGI
    Primary source
    MGI:MGI:1933427
    See related
    Ensembl:ENSMUSG00000021210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akr1c1; Hsd17b5; 3alpha-HSD
    Expression
    Restricted expression toward liver adult (RPKM 103.4) See more

    Genomic context

    See Akr1c6 in Genome Data Viewer
    Location:
    13 A1; 13 2.48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (4434311..4457530)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (4433589..4456776)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C12 Neighboring gene predicted gene 9973 Neighboring gene aldo-keto reductase family 1, member C20 Neighboring gene predicted gene, 40657

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • biosynthesis of prostaglandins, organism-specific biosystem (from BIOCYC)
      biosynthesis of prostaglandins, organism-specific biosystemProstaglandins are potent lipid mediators derived from arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. Prostaglandins are formed by most cells in ou...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    alcohol dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alditol:NADP+ 1-oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    estradiol 17-beta-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    testosterone 17-beta-dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to jasmonic acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    daunorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    doxorubicin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    estradiol 17 beta-dehydrogenase 5
    Names
    17-beta-HSD 5
    17HSD type 5
    aldo-keto reductase family 1, member C1 (aldehyde reductase)
    estradiol 17-beta-dehydrogenase (A-specific)
    hydroxysteroid 17-beta dehydrogenase 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030611.3NP_085114.1  estradiol 17 beta-dehydrogenase 5

      See identical proteins and their annotated locations for NP_085114.1

      Status: PROVISIONAL

      Source sequence(s)
      AK149458
      Consensus CDS
      CCDS26223.1
      UniProtKB/Swiss-Prot
      P70694
      UniProtKB/TrEMBL
      Q3UEM0
      Related
      ENSMUSP00000021630.8, ENSMUST00000021630.14
      Conserved Domains (2) summary
      COG0656
      Location:5323
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16298
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      4434311..4457530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516510.1XP_006516573.1  estradiol 17 beta-dehydrogenase 5 isoform X1

      See identical proteins and their annotated locations for XP_006516573.1

      Conserved Domains (2) summary
      COG0656
      Location:5297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16272
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
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