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    Gda guanine deaminase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83585, updated on 12-Aug-2018

    Summary

    Official Symbol
    Gdaprovided by RGD
    Official Full Name
    guanine deaminaseprovided by RGD
    Primary source
    RGD:621617
    See related
    Ensembl:ENSRNOG00000018282
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cypin
    Summary
    exhibits guanine deaminase activity [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 1007.4), Spleen (RPKM 602.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Gda in Genome Data Viewer
    Location:
    1q51
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (238982542..239057663, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (246267039..246345967, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551544 Neighboring gene uncharacterized LOC103691306 Neighboring gene zinc finger AN1-type containing 5 Neighboring gene uncharacterized LOC100911842 Neighboring gene similar to RIKEN cDNA 1110059E24

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    guanine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    guanine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    guanine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    guanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    guanine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine deaminase
    Names
    GAH
    guanase
    guanine aminase
    guanine aminohydrolase
    NP_113964.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031776.2NP_113964.2  guanine deaminase

      See identical proteins and their annotated locations for NP_113964.2

      Status: PROVISIONAL

      Source sequence(s)
      AF245172
      UniProtKB/TrEMBL
      Q9JKB7
      Related
      ENSRNOP00000024775.4, ENSRNOT00000024775.5
      Conserved Domains (1) summary
      cd01303
      Location:13444
      GDEase; Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      238982542..239057663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      216146233..216221719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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