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    Abcb11 ATP binding cassette subfamily B member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83569, updated on 21-Oct-2018

    Summary

    Official Symbol
    Abcb11provided by RGD
    Official Full Name
    ATP binding cassette subfamily B member 11provided by RGD
    Primary source
    RGD:619930
    See related
    Ensembl:ENSRNOG00000050860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bsep; Spgp
    Summary
    acts as an ATP-dependent bile salt export pump; transports taurochenodeoxycholate, taurocholate, and other bile salts [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 1400.9) See more
    Orthologs

    Genomic context

    See Abcb11 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55480024..55587946, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (62106821..62195528, complement) , (62091490..62092502, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphatase 2-like Neighboring gene SPC25, NDC80 kinetochore complex component Neighboring gene glucose-6-phosphatase catalytic subunit 2 Neighboring gene dehydrogenase/reductase 9 Neighboring gene LDL receptor related protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
     
    canalicular bile acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    canalicular bile acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    bile acid and bile salt transport IEA
    Inferred from Electronic Annotation
    more info
     
    canalicular bile acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    canalicular bile acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug export IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular canaliculus IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    bile salt export pump
    Names
    ATP-binding cassette sub-family B member 11
    ATP-binding cassette, sub-family B (MDR/TAP), member 11
    ATP-binding cassette, subfamily B (MDR/TAP), member 11
    sister of P-glycoprotein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031760.1NP_113948.1  bile salt export pump

      See identical proteins and their annotated locations for NP_113948.1

      Status: PROVISIONAL

      Source sequence(s)
      U69487
      UniProtKB/Swiss-Prot
      O70127
      Related
      ENSRNOP00000064279.2, ENSRNOT00000075107.2
      Conserved Domains (1) summary
      cl28181
      Location:1501314
      AAA; ATPases associated with a variety of cellular activities

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      55480024..55587946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      53579155..53674029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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