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    Cyr61 cysteine-rich, angiogenic inducer, 61 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83476, updated on 12-Aug-2018

    Summary

    Official Symbol
    Cyr61provided by RGD
    Official Full Name
    cysteine-rich, angiogenic inducer, 61provided by RGD
    Primary source
    RGD:620763
    See related
    Ensembl:ENSRNOG00000014350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    an extracellular heparin binding protein involved in supporting smooth muscle cell adhesion, promoting cell migration, and enhancing growth factor-stimulated mitogenesis [RGD, Feb 2006]
    Expression
    Biased expression in Lung (RPKM 151.5), Heart (RPKM 100.4) and 8 other tissues See more
    Orthologs

    Genomic context

    See Cyr61 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (251529354..251532312, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (270055954..270058912, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene collagen type XXIV alpha 1 chain Neighboring gene uncharacterized LOC103691726 Neighboring gene zinc finger, HIT-type containing 6 Neighboring gene uncharacterized LOC102553018 Neighboring gene uncharacterized LOC108350132 Neighboring gene dimethylarginine dimethylaminohydrolase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC93040

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heparin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process involved in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    atrioventricular valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chondroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    chondroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    chorio-allantoic fusion IEA
    Inferred from Electronic Annotation
    more info
     
    chorio-allantoic fusion ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    intussusceptive angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    intussusceptive angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing, spreading of cells IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein CYR61
    Names
    CCN family member 1
    IBP-10
    IGF-binding protein 10
    IGFBP-10
    cysteine rich protein 61
    insulin-like growth factor-binding protein 10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031327.2NP_112617.2  protein CYR61 precursor

      See identical proteins and their annotated locations for NP_112617.2

      Status: PROVISIONAL

      Source sequence(s)
      AF218568
      UniProtKB/Swiss-Prot
      Q9ES72
      Related
      ENSRNOP00000019501.2, ENSRNOT00000019501.4
      Conserved Domains (4) summary
      pfam00007
      Location:291373
      Cys_knot; Cystine-knot domain
      smart00209
      Location:230270
      TSP1; Thrombospondin type 1 repeats
      smart00214
      Location:100159
      VWC; von Willebrand factor (vWF) type C domain
      pfam00219
      Location:2678
      IGFBP; Insulin-like growth factor binding protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      251529354..251532312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      226551241..226554210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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