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    MED21 mediator 21 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825815, updated on 22-Feb-2019

    Summary

    Gene symbol
    MED21
    Gene description
    mediator 21
    Primary source
    Araport:AT4G04780
    Locus tag
    AT4G04780
    Gene type
    protein coding
    RNA name
    mediator 21
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mediator 21; T4B21.8; T4B21_8
    Summary
    Encodes the med21 subunit of the mediator complex which is involved in transcriptional regulation. MED21 interacts physically with the E3 ligase HUB1 and this interaction may be important in mediation defense responses to fungal pathogens.

    Genomic context

    See MED21 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (2432252..2433635)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene ATP binding cassette protein 1 Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    NM_116716.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to fungus, incompatible interaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mediator complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus ISM
    Inferred from Sequence Model
    more info
     
    polar nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    mediator 21
    NP_192387.2
    • mediator 21 (MED21); CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med21 (InterPro:IPR021384); Has 261 Blast hits to 261 proteins in 70 species: Archae - 0; Bacteria - 2; Metazoa - 108; Fungi - 6; Plants - 134; Viruses - 7; Other Eukaryotes - 4 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2432252..2433635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116716.5NP_192387.2  mediator 21 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192387.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LU16
      Conserved Domains (1) summary
      pfam11221
      Location:2130
      Med21; Subunit 21 of Mediator complex
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