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    GTPBP6 GTP binding protein 6 (putative) [ Homo sapiens (human) ]

    Gene ID: 8225, updated on 4-Jul-2021

    Summary

    Official Symbol
    GTPBP6provided by HGNC
    Official Full Name
    GTP binding protein 6 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:30189
    See related
    Ensembl:ENSG00000178605 MIM:300124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGPL
    Summary
    This gene encodes a GTP binding protein and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 14.1), spleen (RPKM 12.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GTPBP6 in Genome Data Viewer
    Location:
    X;Y
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (303352..318819, complement)
    109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (303352..318819, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (221417..230886, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (171417..180886, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 1 Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene protein phosphatase 2 regulatory subunit B''beta

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 1 Neighboring gene long intergenic non-protein coding RNA 685 Neighboring gene protein phosphatase 2 regulatory subunit B''beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20977, FLJ22809, FLJ56662, FLJ56805, FLJ90047

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    putative GTP-binding protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034126.1 RefSeqGene

      Range
      5001..19070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_012227.4NP_036359.3  putative GTP-binding protein 6

      See identical proteins and their annotated locations for NP_036359.3

      Status: REVIEWED

      Source sequence(s)
      BX000483, FO681518
      Consensus CDS
      CCDS75943.1
      UniProtKB/Swiss-Prot
      O43824
      UniProtKB/TrEMBL
      H0Y2S1
      Related
      ENSP00000316598.5, ENST00000326153.9
      Conserved Domains (1) summary
      COG2262
      Location:116513
      HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      303352..318819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724447.4XP_006724510.1  putative GTP-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006724510.1

      Conserved Domains (4) summary
      cd01878
      Location:115316
      HflX; HflX GTPase family
      pfam02421
      Location:157311
      FeoB_N; Ferrous iron transport protein B
      pfam13167
      Location:169
      GTP-bdg_N; GTP-binding GTPase N-terminal
      pfam16360
      Location:73144
      GTP-bdg_M; GTP-binding GTPase Middle Region
    2. XM_011546184.3XP_011544486.1  putative GTP-binding protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011544486.1

      Conserved Domains (4) summary
      cd01878
      Location:74275
      HflX; HflX GTPase family
      pfam02421
      Location:116270
      FeoB_N; Ferrous iron transport protein B
      pfam13167
      Location:728
      GTP-bdg_N; GTP-binding GTPase N-terminal
      pfam16360
      Location:32103
      GTP-bdg_M; GTP-binding GTPase Middle Region

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

      Range
      303352..318819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724868.4XP_006724931.1  putative GTP-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006724931.1

      Conserved Domains (4) summary
      cd01878
      Location:115316
      HflX; HflX GTPase family
      pfam02421
      Location:157311
      FeoB_N; Ferrous iron transport protein B
      pfam13167
      Location:169
      GTP-bdg_N; GTP-binding GTPase N-terminal
      pfam16360
      Location:73144
      GTP-bdg_M; GTP-binding GTPase Middle Region
    2. XM_011545637.3XP_011543939.1  putative GTP-binding protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011543939.1

      Conserved Domains (4) summary
      cd01878
      Location:74275
      HflX; HflX GTPase family
      pfam02421
      Location:116270
      FeoB_N; Ferrous iron transport protein B
      pfam13167
      Location:728
      GTP-bdg_N; GTP-binding GTPase N-terminal
      pfam16360
      Location:32103
      GTP-bdg_M; GTP-binding GTPase Middle Region
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