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    CAPG capping actin protein, gelsolin like [ Homo sapiens (human) ]

    Gene ID: 822, updated on 12-Aug-2018

    Summary

    Official Symbol
    CAPGprovided by HGNC
    Official Full Name
    capping actin protein, gelsolin likeprovided by HGNC
    Primary source
    HGNC:HGNC:1474
    See related
    Ensembl:ENSG00000042493 MIM:153615; Vega:OTTHUMG00000130183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCP; AFCP; HEL-S-66
    Summary
    This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Broad expression in lung (RPKM 44.7), esophagus (RPKM 37.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See CAPG in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (85394748..85418467, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85621871..85641197, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene retinol saturase Neighboring gene ELMO domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 113, pseudogene Neighboring gene uncharacterized LOC105374841 Neighboring gene SH2 domain containing 6 Neighboring gene RNA, U7 small nuclear 64 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with CAPG in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of capping protein gelsolin-like (CAPG) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    NOT extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT positive regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-containing complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    F-actin capping protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Flemming body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    macrophage-capping protein
    Names
    actin-regulatory protein CAP-G
    capping protein (actin filament), gelsolin-like
    epididymis secretory protein Li 66
    gelsolin-like capping protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256139.1NP_001243068.1  macrophage-capping protein isoform 1

      See identical proteins and their annotated locations for NP_001243068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AK130130, AK313898, AU099216, BU626913
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      P40121
      UniProtKB/TrEMBL
      B2R9S4, V9HW69
      Related
      ENSP00000386965.1, OTTHUMP00000203057, ENST00000409724.5, OTTHUMT00000329381
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    2. NM_001256140.1NP_001243069.1  macrophage-capping protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK130130, AK225374, BU626913
      Consensus CDS
      CCDS58715.1
      UniProtKB/Swiss-Prot
      P40121
      Related
      ENSP00000387063.1, OTTHUMP00000203059, ENST00000409921.5, OTTHUMT00000329383
      Conserved Domains (3) summary
      cd11289
      Location:137208
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:236331
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    3. NM_001320732.1NP_001307661.1  macrophage-capping protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      BG762391, FJ224312
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      P40121
      UniProtKB/TrEMBL
      V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    4. NM_001320733.1NP_001307662.1  macrophage-capping protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      BG762114, FJ224312
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      P40121
      UniProtKB/TrEMBL
      V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    5. NM_001320734.1NP_001307663.1  macrophage-capping protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK130130, BU172582, FJ224312
      UniProtKB/TrEMBL
      V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:221315
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    6. NM_001747.3NP_001738.2  macrophage-capping protein isoform 1

      See identical proteins and their annotated locations for NP_001738.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AK130130, BU626913
      Consensus CDS
      CCDS1974.1
      UniProtKB/Swiss-Prot
      P40121
      UniProtKB/TrEMBL
      V9HW69
      Related
      ENSP00000263867.4, OTTHUMP00000203056, ENST00000263867.8, OTTHUMT00000329380
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      85394748..85418467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533122.1XP_011531424.1  macrophage-capping protein isoform X1

      See identical proteins and their annotated locations for XP_011531424.1

      UniProtKB/Swiss-Prot
      P40121
      UniProtKB/TrEMBL
      V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    2. XM_011533123.1XP_011531425.1  macrophage-capping protein isoform X1

      See identical proteins and their annotated locations for XP_011531425.1

      UniProtKB/Swiss-Prot
      P40121
      UniProtKB/TrEMBL
      V9HW69
      Conserved Domains (3) summary
      cd11289
      Location:137225
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:17120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:251346
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
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