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    SFXN3 sideroflexin 3 [ Homo sapiens (human) ]

    Gene ID: 81855, updated on 2-Jul-2021

    Summary

    Official Symbol
    SFXN3provided by HGNC
    Official Full Name
    sideroflexin 3provided by HGNC
    Primary source
    HGNC:HGNC:16087
    See related
    Ensembl:ENSG00000107819 MIM:615571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFX3; SLC56A3; BA108L7.2
    Expression
    Ubiquitous expression in small intestine (RPKM 25.7), duodenum (RPKM 19.3) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SFXN3 in Genome Data Viewer
    Location:
    10q24.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101031234..101041243)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102790991..102800998)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper tumor suppressor 2 Neighboring gene PDZ domain containing 7 Neighboring gene uncharacterized LOC107984262 Neighboring gene Sharpr-MPRA regulatory region 11881 Neighboring gene Kazal type serine peptidase inhibitor domain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of sideroflexin 3 (SFXN3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001388027.1NP_001374956.1  sideroflexin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13329
      Mtc; Tricarboxylate carrier
    2. NM_001388028.1NP_001374957.1  sideroflexin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13329
      Mtc; Tricarboxylate carrier
    3. NM_001388029.1NP_001374958.1  sideroflexin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13325
      Mtc; Tricarboxylate carrier
    4. NM_001388030.1NP_001374959.1  sideroflexin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13325
      Mtc; Tricarboxylate carrier
    5. NM_001388031.1NP_001374960.1  sideroflexin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13325
      Mtc; Tricarboxylate carrier
    6. NM_001388032.1NP_001374961.1  sideroflexin-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13308
      Mtc; Tricarboxylate carrier
    7. NM_001388033.1NP_001374962.1  sideroflexin-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:13285
      Mtc; Tricarboxylate carrier
    8. NM_001388034.1NP_001374963.1  sideroflexin-3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:1230
      Mtc; Tricarboxylate carrier
    9. NM_001388035.1NP_001374964.1  sideroflexin-3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Conserved Domains (1) summary
      pfam03820
      Location:1230
      Mtc; Tricarboxylate carrier
    10. NM_030971.6NP_112233.3  sideroflexin-3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL133215
      Consensus CDS
      CCDS7508.2
      Related
      ENSP00000224807.5, ENST00000224807.9

    RNA

    1. NR_157572.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    2. NR_170874.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    3. NR_170875.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    4. NR_170876.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    5. NR_170877.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    6. NR_170878.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    7. NR_170879.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215
    8. NR_170880.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133215

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      101031234..101041243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_945825.3 RNA Sequence

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