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    CSRNP2 cysteine and serine rich nuclear protein 2 [ Homo sapiens (human) ]

    Gene ID: 81566, updated on 17-Jun-2019

    Summary

    Official Symbol
    CSRNP2provided by HGNC
    Official Full Name
    cysteine and serine rich nuclear protein 2provided by HGNC
    Primary source
    HGNC:HGNC:16006
    See related
    Ensembl:ENSG00000110925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C12orf2; PPP1R72; TAIP-12; C12orf22; FAM130A1
    Summary
    The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in testis (RPKM 16.6), brain (RPKM 11.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See CSRNP2 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (51061205..51083654, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (51454988..51477454, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 2 Neighboring gene RNA, U6 small nuclear 87, pseudogene Neighboring gene RNA, U6 small nuclear 1273, pseudogene Neighboring gene LETM1 domain containing 1 Neighboring gene transcription factor CP2 Neighboring gene ribosomal protein L35a pseudogene 29 Neighboring gene prohibitin pseudogene 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25576

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    cysteine/serine-rich nuclear protein 2
    Names
    CSRNP-2
    TGF-beta-induced apoptosis protein 12
    family with sequence similarity 130, member A1
    protein phosphatase 1, regulatory subunit 72

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030809.3NP_110436.1  cysteine/serine-rich nuclear protein 2

      See identical proteins and their annotated locations for NP_110436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AJ298133, BM975428, DB059091
      Consensus CDS
      CCDS8807.1
      UniProtKB/Swiss-Prot
      Q9H175
      Related
      ENSP00000228515.1, ENST00000228515.5
      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    RNA

    1. NR_045072.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AJ298133, BM975428, DB460042

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      51061205..51083654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449216.1XP_024304984.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    2. XM_024449214.1XP_024304982.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    3. XM_024449215.1XP_024304983.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    4. XM_024449213.1XP_024304981.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    5. XM_024449210.1XP_024304978.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    6. XM_006719621.3XP_006719684.1  cysteine/serine-rich nuclear protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006719684.1

      UniProtKB/Swiss-Prot
      Q9H175
      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    7. XM_024449211.1XP_024304979.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    8. XM_024449212.1XP_024304980.1  cysteine/serine-rich nuclear protein 2 isoform X1

      Conserved Domains (1) summary
      pfam16019
      Location:63278
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    9. XM_017019991.2XP_016875480.1  cysteine/serine-rich nuclear protein 2 isoform X2

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