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    APOL6 apolipoprotein L6 [ Homo sapiens (human) ]

    Gene ID: 80830, updated on 8-Jul-2018
    Official Symbol
    APOL6provided by HGNC
    Official Full Name
    apolipoprotein L6provided by HGNC
    Primary source
    HGNC:HGNC:14870
    See related
    Ensembl:ENSG00000221963 MIM:607256; Vega:OTTHUMG00000150615
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APOLVI; APOL-VI
    Summary
    This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 14.3), liver (RPKM 13.1) and 24 other tissues See more
    Orthologs
    See APOL6 in Genome Data Viewer
    Location:
    22q12.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (35648316..35668409)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36044424..36064456)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene myoglobin Neighboring gene uncharacterized LOC284912 Neighboring gene mitochondrial ribosomal protein S16 pseudogene 3 Neighboring gene apolipoprotein L5

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Infectious wild type HIV-1 production is restricted by 293T cells over-expressing APOL6 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of apolipoprotein L, 6 (APOL6) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ38562, FLJ90164, MGC57495, DKFZp667M075

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    apolipoprotein L6
    Names
    apolipoprotein L, 6
    apolipoprotein L-VI

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030641.3NP_085144.1  apolipoprotein L6

      See identical proteins and their annotated locations for NP_085144.1

      Status: REVIEWED

      Source sequence(s)
      BC047864, BM982940, BU585026, Z79996
      Consensus CDS
      CCDS13919.1
      UniProtKB/Swiss-Prot
      Q9BWW8
      UniProtKB/TrEMBL
      B3KTP4
      Related
      ENSP00000386280.3, OTTHUMP00000197934, ENST00000409652.4, OTTHUMT00000319081
      Conserved Domains (1) summary
      pfam05461
      Location:14292
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

      Range
      35648316..35668409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530392.3XP_011528694.1  apolipoprotein L6 isoform X1

      See identical proteins and their annotated locations for XP_011528694.1

      UniProtKB/Swiss-Prot
      Q9BWW8
      UniProtKB/TrEMBL
      B3KTP4
      Conserved Domains (1) summary
      pfam05461
      Location:14292
      ApoL; Apolipoprotein L
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