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    WDR26 WD repeat domain 26 [ Homo sapiens (human) ]

    Gene ID: 80232, updated on 12-Aug-2018

    Summary

    Official Symbol
    WDR26provided by HGNC
    Official Full Name
    WD repeat domain 26provided by HGNC
    Primary source
    HGNC:HGNC:21208
    See related
    Ensembl:ENSG00000162923 MIM:617424; Vega:OTTHUMG00000037636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDW2; GID7; MIP2; SKDEAS
    Summary
    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 30.1), esophagus (RPKM 28.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See WDR26 in Genome Data Viewer
    Location:
    1q42.11-q42.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (224385143..224434767, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (224572845..224622001, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nuclear VCP-like Neighboring gene RNA, U6 small nuclear 1008, pseudogene Neighboring gene cornichon family AMPA receptor auxiliary protein 4 Neighboring gene microRNA 4742 Neighboring gene cornichon family AMPA receptor auxiliary protein 3 Neighboring gene aldehyde reductase family 1 member B1 pseudogene 1 Neighboring gene uncharacterized LOC102723817

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    SKRABAN-DEARDORFF SYNDROME
    MedGen: C4539927 OMIM: 617616 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21016

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 26
    Names
    CUL4- and DDB1-associated WDR protein 2
    GID complex subunit 7 homolog
    myocardial ischemic preconditioning upregulated protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047198.1 RefSeqGene

      Range
      5001..54157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001115113.2NP_001108585.2  WD repeat-containing protein 26 isoform b

      See identical proteins and their annotated locations for NP_001108585.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC099790, AY221751, BF509638, BU673957, CN283908
      UniProtKB/Swiss-Prot
      Q9H7D7
      Conserved Domains (3) summary
      smart00668
      Location:156215
      CTLH; C-terminal to LisH motif
      cd00200
      Location:333625
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:343383
      7WD40; WD40 repeat [structural motif]
    2. NM_025160.6NP_079436.4  WD repeat-containing protein 26 isoform a

      See identical proteins and their annotated locations for NP_079436.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB209887, AC099790, BU673957, CN283908
      Consensus CDS
      CCDS31037.2
      UniProtKB/Swiss-Prot
      Q9H7D7
      Related
      ENSP00000408108.2, OTTHUMP00000035756, ENST00000414423.6, OTTHUMT00000091760
      Conserved Domains (3) summary
      smart00668
      Location:156231
      CTLH; C-terminal to LisH motif
      cd00200
      Location:349641
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:359399
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      224385143..224434767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711817.4XP_006711880.1  WD repeat-containing protein 26 isoform X1

      See identical proteins and their annotated locations for XP_006711880.1

      Conserved Domains (3) summary
      smart00668
      Location:156231
      CTLH; C-terminal to LisH motif
      cd00200
      Location:348640
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:358398
      7WD40; WD40 repeat [structural motif]
    2. XM_005273273.5XP_005273330.1  WD repeat-containing protein 26 isoform X2

      See identical proteins and their annotated locations for XP_005273330.1

      Conserved Domains (3) summary
      smart00668
      Location:156231
      CTLH; C-terminal to LisH motif
      sd00039
      Location:359399
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:349592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_011544281.2XP_011542583.1  WD repeat-containing protein 26 isoform X3

      See identical proteins and their annotated locations for XP_011542583.1

      Conserved Domains (3) summary
      COG2319
      Location:136431
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:139431
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:149189
      7WD40; WD40 repeat [structural motif]
    4. XM_017002396.1XP_016857885.1  WD repeat-containing protein 26 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:136431
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:139431
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:149189
      7WD40; WD40 repeat [structural motif]
    5. XM_011544282.2XP_011542584.1  WD repeat-containing protein 26 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:89384
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:92384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:102142
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_001737437.2 RNA Sequence

    2. XR_002957643.1 RNA Sequence

    3. XR_002957642.1 RNA Sequence

    4. XR_002957644.1 RNA Sequence

    5. XR_247043.4 RNA Sequence

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