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    PTGES2 prostaglandin E synthase 2 [ Homo sapiens (human) ]

    Gene ID: 80142, updated on 5-Aug-2018

    Summary

    Official Symbol
    PTGES2provided by HGNC
    Official Full Name
    prostaglandin E synthase 2provided by HGNC
    Primary source
    HGNC:HGNC:17822
    See related
    Ensembl:ENSG00000148334 MIM:608152; Vega:OTTHUMG00000020730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBF1; GBF-1; PGES2; C9orf15; mPGES-2
    Summary
    The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
    Expression
    Ubiquitous expression in heart (RPKM 13.3), kidney (RPKM 10.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See PTGES2 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (128120693..128128462, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130882972..130890741, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 25 Neighboring gene SLC25A25 antisense RNA 1 Neighboring gene PTGES2 antisense RNA 1 (head to head) Neighboring gene lipocalin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Arachidonic acid metabolism, conserved biosystem (from KEGG)
      Arachidonic acid metabolism, conserved biosystem
      Arachidonic acid metabolism
    • C20 prostanoid biosynthesis, organism-specific biosystem (from BIOCYC)
      C20 prostanoid biosynthesis, organism-specific biosystemGeneral Background A subclass of eicosanoids, the C20 prostanoids comprise of prostaglandins, thromboxanes and prostacyclins. They are all lipid compounds derived from the ω6 essential fatty ...
    • C20 prostanoid biosynthesis, conserved biosystem (from BIOCYC)
      C20 prostanoid biosynthesis, conserved biosystemGeneral Background A subclass of eicosanoids, the C20 prostanoids comprise of prostaglandins, thromboxanes and prostacyclins. They are all lipid compounds derived from the ω6 essential fatty ...
    • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
      Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystem (from REACTOME)
      Synthesis of Prostaglandins (PG) and Thromboxanes (TX), organism-specific biosystemThe bioactive prostaglandin (PG) signalling molecules, including PGA2, PGE2, PGF2a, and PGI2 (prostacyclin) are synthesised from arachidonic acid and its products by various prostaglandin synthase ty...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ14038, MGC11289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostaglandin-E synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostaglandin-E synthase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein disulfide oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cyclooxygenase pathway TAS
    Traceable Author Statement
    more info
     
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prostaglandin E synthase 2
    Names
    GATE-binding factor 1
    gamma-interferon-activated transcriptional element-binding factor 1
    mPGE synthase-2
    membrane-associated prostaglandin E synthase 2
    microsomal prostaglandin E synthase-2
    prostaglandin-H(2) E-isomerase
    NP_001243264.1
    NP_079348.1
    NP_945176.1
    XP_005252296.1
    XP_011517352.1
    XP_011517353.1
    XP_024303456.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012488.1 RefSeqGene

      Range
      4734..12503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256335.1NP_001243264.1  prostaglandin E synthase 2 isoform 2

      See identical proteins and their annotated locations for NP_001243264.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode isoform 2.
      Source sequence(s)
      AL590708, BC011613, BG481657, BX493085
      UniProtKB/Swiss-Prot
      Q9H7Z7
      UniProtKB/TrEMBL
      A6NHH0
      Related
      ENSP00000482913.1, ENST00000617202.4
      Conserved Domains (1) summary
      cd03197
      Location:33179
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    2. NM_025072.6NP_079348.1  prostaglandin E synthase 2 isoform 1

      See identical proteins and their annotated locations for NP_079348.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK057049, AL590708, BC011613, BG823488
      Consensus CDS
      CCDS6891.1
      UniProtKB/Swiss-Prot
      Q9H7Z7
      UniProtKB/TrEMBL
      B3KPZ2
      Related
      ENSP00000345341.6, OTTHUMP00000022231, ENST00000338961.10, OTTHUMT00000054339
      Conserved Domains (2) summary
      cd03197
      Location:224370
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
      cd03040
      Location:101177
      GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...
    3. NM_198938.2NP_945176.1  prostaglandin E synthase 2 isoform 2

      See identical proteins and their annotated locations for NP_945176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1. Both variants 2 and 5 encode isoform 2.
      Source sequence(s)
      AK057049, AK301618, AL590708, BC011613
      UniProtKB/Swiss-Prot
      Q9H7Z7
      UniProtKB/TrEMBL
      A6NHH0, B3KPZ2, B4DWP1
      Related
      ENSP00000277462.5, ENST00000277462.9
      Conserved Domains (1) summary
      cd03197
      Location:33179
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      128120693..128128462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519050.1XP_011517352.1  prostaglandin E synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_011517352.1

      UniProtKB/TrEMBL
      A6NHH0
      Conserved Domains (1) summary
      cd03197
      Location:33179
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    2. XM_024447688.1XP_024303456.1  prostaglandin E synthase 2 isoform X1

      Conserved Domains (1) summary
      cd03197
      Location:33179
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    3. XM_011519051.3XP_011517353.1  prostaglandin E synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_011517353.1

      UniProtKB/TrEMBL
      A6NHH0
      Conserved Domains (1) summary
      cd03197
      Location:33179
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    4. XM_005252239.2XP_005252296.1  prostaglandin E synthase 2 isoform X1

      See identical proteins and their annotated locations for XP_005252296.1

      UniProtKB/TrEMBL
      A6NHH0
      Conserved Domains (1) summary
      cd03197
      Location:33179
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2

    RNA

    1. XR_001746383.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198939.1: Suppressed sequence

      Description
      NM_198939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_198940.1: Suppressed sequence

      Description
      NM_198940.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    3. NR_027812.1: Suppressed sequence

      Description
      NR_027812.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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