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    VPS37B VPS37B subunit of ESCRT-I [ Homo sapiens (human) ]

    Gene ID: 79720, updated on 8-Aug-2021

    Summary

    Official Symbol
    VPS37Bprovided by HGNC
    Official Full Name
    VPS37B subunit of ESCRT-Iprovided by HGNC
    Primary source
    HGNC:HGNC:25754
    See related
    Ensembl:ENSG00000139722 MIM:610037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in esophagus (RPKM 9.2), colon (RPKM 9.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See VPS37B in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (122865330..122896143, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123349877..123380671, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 62 Neighboring gene huntingtin interacting protein 1 related Neighboring gene ATP binding cassette subfamily B member 9 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 2 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Tsg 101, VPS 28, and VPS 37B form the human endosomal sorting complex required for transport (ESCRT-I), which is required for HIV-1 Gag budding and virus infectivity PubMed
    nucleocapsid gag GST-fused NCp6 fragment binds ESCRT-I subunits such as MVB12B, VPS37B, VPS28, and TSG101 PubMed
    gag ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6 PubMed
    p6 gag GST-fused NCp6 fragment binds ESCRT-I subunits such as MVB12B, VPS37B, VPS28, and TSG101 PubMed
    gag ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12750

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ESCRT I complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ESCRT I complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vacuolar protein sorting-associated protein 37B
    Names
    ESCRT-I complex subunit VPS37B
    VPS37B, ESCRT-I subunit
    hVps37B
    vacuolar protein sorting 37 homolog B
    vacuolar protein sorting 37B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024667.3NP_078943.1  vacuolar protein sorting-associated protein 37B

      See identical proteins and their annotated locations for NP_078943.1

      Status: VALIDATED

      Source sequence(s)
      AK022812, BU629695
      Consensus CDS
      CCDS9239.1
      UniProtKB/Swiss-Prot
      Q9H9H4
      UniProtKB/TrEMBL
      A0A024RBU0
      Related
      ENSP00000267202.2, ENST00000267202.7
      Conserved Domains (1) summary
      pfam07200
      Location:11156
      Mod_r; Modifier of rudimentary (Mod(r)) protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      122865330..122896143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538743.2XP_011537045.1  vacuolar protein sorting-associated protein 37B isoform X1

      Conserved Domains (1) summary
      pfam07200
      Location:96211
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    2. XM_011538745.2XP_011537047.1  vacuolar protein sorting-associated protein 37B isoform X2

      Conserved Domains (1) summary
      pfam07200
      Location:20134
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    3. XM_005253622.3XP_005253679.1  vacuolar protein sorting-associated protein 37B isoform X3

      See identical proteins and their annotated locations for XP_005253679.1

      Conserved Domains (1) summary
      pfam07200
      Location:10124
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    4. XM_006719602.4XP_006719665.1  vacuolar protein sorting-associated protein 37B isoform X3

      See identical proteins and their annotated locations for XP_006719665.1

      Conserved Domains (1) summary
      pfam07200
      Location:10124
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    5. XM_017019970.1XP_016875459.1  vacuolar protein sorting-associated protein 37B isoform X4

    6. XM_017019972.1XP_016875461.1  vacuolar protein sorting-associated protein 37B isoform X6

    7. XM_017019971.1XP_016875460.1  vacuolar protein sorting-associated protein 37B isoform X5

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