Format

Send to:

Choose Destination
    • Showing Current items.

    DCAF10 DDB1 and CUL4 associated factor 10 [ Homo sapiens (human) ]

    Gene ID: 79269, updated on 7-Oct-2018

    Summary

    Official Symbol
    DCAF10provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 10provided by HGNC
    Primary source
    HGNC:HGNC:23686
    See related
    Ensembl:ENSG00000122741 Vega:OTTHUMG00000019934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WDR32
    Expression
    Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See DCAF10 in Genome Data Viewer
    Location:
    9p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (37800554..37867669)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37800551..37867666)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RNA, 7SK small nuclear pseudogene 171 Neighboring gene tRNA methyltransferase 10B Neighboring gene uncharacterized LOC105376037 Neighboring gene exosome component 3 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene SH2 domain containing adaptor protein B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23201, MGC10765, MGC131781

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 10
    Names
    WD repeat domain 32
    WD repeat-containing protein 32

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286810.1NP_001273739.1  DDB1- and CUL4-associated factor 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK309712, AL138752, BC108686, CB045943
      Consensus CDS
      CCDS75835.1
      UniProtKB/Swiss-Prot
      Q5QP82
      UniProtKB/TrEMBL
      A0A0A0MQT4
      Related
      ENSP00000242323.8, ENST00000242323.8
      Conserved Domains (2) summary
      sd00039
      Location:234
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:9146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_024345.4NP_077321.3  DDB1- and CUL4-associated factor 10 isoform a

      See identical proteins and their annotated locations for NP_077321.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL138752, BC108686, CB045943, HY015327
      Consensus CDS
      CCDS6613.2
      UniProtKB/Swiss-Prot
      Q5QP82
      Related
      ENSP00000366953.3, OTTHUMP00000021395, ENST00000377724.7, OTTHUMT00000052485
      Conserved Domains (4) summary
      smart00320
      Location:517555
      WD40; WD40 repeats
      COG2319
      Location:171334
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:172207
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:164319
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      37800554..37867669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251577.4XP_005251634.1  DDB1- and CUL4-associated factor 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5QP82
      Conserved Domains (3) summary
      COG2319
      Location:169518
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:172207
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:169519
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017015128.1XP_016870617.1  DDB1- and CUL4-associated factor 10 isoform X3

    3. XM_005251578.4XP_005251635.1  DDB1- and CUL4-associated factor 10 isoform X2

      Conserved Domains (3) summary
      smart00320
      Location:451489
      WD40; WD40 repeats
      COG2319
      Location:169489
      WD40; WD40 repeat [General function prediction only]
      cl02567
      Location:164223
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_017015129.1XP_016870618.1  DDB1- and CUL4-associated factor 10 isoform X4

      Conserved Domains (1) summary
      smart00320
      Location:216254
      WD40; WD40 repeats

    RNA

    1. XR_002956808.1 RNA Sequence

    2. XR_929331.2 RNA Sequence

    3. XR_002956809.1 RNA Sequence

    4. XR_002956810.1 RNA Sequence

    Support Center