Format

Send to:

Choose Destination
    • Showing Current items.

    Ndor1 NADPH dependent diflavin oxidoreductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 78797, updated on 16-Jul-2019

    Summary

    Official Symbol
    Ndor1provided by MGI
    Official Full Name
    NADPH dependent diflavin oxidoreductase 1provided by MGI
    Primary source
    MGI:MGI:1926047
    See related
    Ensembl:ENSMUSG00000006471 Ensembl:ENSMUSG00000115074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NR1; Ndor; Ubc-cre; 4930447P04Rik; Tg(UBC-cre/ERT2)1Ejb
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.6), spleen adult (RPKM 13.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ndor1 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (25244813..25255443, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (25100339..25110934, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cysteine rich tail 1 Neighboring gene ring finger protein 208 Neighboring gene transmembrane protein 203 Neighboring gene taperin Neighboring gene SS nuclear autoantigen 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    NADPH-hemoprotein reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to menadione ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADPH-dependent diflavin oxidoreductase 1
    Names
    NADPH-dependent FMN and FAD-containing oxidoreductase
    Tg(UBC-cre)1Ejb
    Tg(UBC-cre/ESR1)1Ejb
    NP_001075945.1
    NP_001239470.1
    NP_001239471.1
    XP_006498504.1
    XP_006498505.1
    XP_006498506.1
    XP_006498507.1
    XP_006498508.1
    XP_006498509.1
    XP_006498510.1
    XP_006498511.1
    XP_006498513.1
    XP_006498514.1
    XP_006498515.1
    XP_006498518.1
    XP_011237515.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082476.2NP_001075945.1  NADPH-dependent diflavin oxidoreductase 1 isoform 1

      See identical proteins and their annotated locations for NP_001075945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK019617, AL732309
      Consensus CDS
      CCDS38069.1
      UniProtKB/Swiss-Prot
      A2AI05
      Related
      ENSMUSP00000109989.2, ENSMUST00000114349.8
      Conserved Domains (3) summary
      COG0369
      Location:6597
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:8145
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:212597
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    2. NM_001252541.1NP_001239470.1  NADPH-dependent diflavin oxidoreductase 1 isoform 2

      See identical proteins and their annotated locations for NP_001239470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK163207, AL732309
      Consensus CDS
      CCDS57157.1
      UniProtKB/Swiss-Prot
      A2AI05
      Related
      ENSMUSP00000097903.3, ENSMUST00000100329.9
      Conserved Domains (3) summary
      COG0369
      Location:6530
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:8123
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:145530
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    3. NM_001252542.1NP_001239471.1  NADPH-dependent diflavin oxidoreductase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK143124, AL732309
      Related
      ENSMUSP00000154261.1, ENSMUST00000228052.1
      Conserved Domains (3) summary
      COG0369
      Location:1450
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:176
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:143450
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      25244813..25255443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498446.3XP_006498509.1  NADPH-dependent diflavin oxidoreductase 1 isoform X5

      Conserved Domains (3) summary
      COG0369
      Location:6519
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:8145
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:212519
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    2. XM_006498442.3XP_006498505.1  NADPH-dependent diflavin oxidoreductase 1 isoform X2

      Conserved Domains (3) summary
      COG0369
      Location:98570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263570
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    3. XM_006498455.3XP_006498518.1  NADPH-dependent diflavin oxidoreductase 1 isoform X11

      Conserved Domains (3) summary
      COG0369
      Location:98570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263570
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    4. XM_006498441.3XP_006498504.1  NADPH-dependent diflavin oxidoreductase 1 isoform X1

      Conserved Domains (3) summary
      COG0369
      Location:98570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263570
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    5. XM_006498450.3XP_006498513.1  NADPH-dependent diflavin oxidoreductase 1 isoform X8

      See identical proteins and their annotated locations for XP_006498513.1

      Conserved Domains (3) summary
      COG0369
      Location:98570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263585
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    6. XM_006498447.3XP_006498510.1  NADPH-dependent diflavin oxidoreductase 1 isoform X6

      Conserved Domains (3) summary
      COG0369
      Location:98602
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263602
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    7. XM_006498444.3XP_006498507.1  NADPH-dependent diflavin oxidoreductase 1 isoform X4

      See identical proteins and their annotated locations for XP_006498507.1

      Conserved Domains (3) summary
      COG0369
      Location:98602
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263602
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    8. XM_006498452.2XP_006498515.1  NADPH-dependent diflavin oxidoreductase 1 isoform X9

      Conserved Domains (3) summary
      COG0369
      Location:1450
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:176
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:143450
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    9. XM_006498448.3XP_006498511.1  NADPH-dependent diflavin oxidoreductase 1 isoform X7

      Conserved Domains (3) summary
      COG0369
      Location:25497
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:23123
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:190497
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    10. XM_011239213.2XP_011237515.1  NADPH-dependent diflavin oxidoreductase 1 isoform X10

      Conserved Domains (1) summary
      cl06868
      Location:59366
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    11. XM_006498443.3XP_006498506.1  NADPH-dependent diflavin oxidoreductase 1 isoform X3

      Conserved Domains (3) summary
      COG0369
      Location:98648
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263648
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    12. XM_006498451.3XP_006498514.1  NADPH-dependent diflavin oxidoreductase 1 isoform X8

      See identical proteins and their annotated locations for XP_006498514.1

      Conserved Domains (3) summary
      COG0369
      Location:98570
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263585
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    13. XM_006498445.3XP_006498508.1  NADPH-dependent diflavin oxidoreductase 1 isoform X4

      See identical proteins and their annotated locations for XP_006498508.1

      Conserved Domains (3) summary
      COG0369
      Location:98602
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:96196
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:263602
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RNA

    1. XR_374139.3 RNA Sequence

    2. XR_374138.3 RNA Sequence

    3. XR_866029.2 RNA Sequence

    4. XR_866028.2 RNA Sequence

    5. XR_374141.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178239.2: Suppressed sequence

      Description
      NM_178239.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Support Center