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    LRRK2 leucine rich repeat kinase 2 [ Sus scrofa (pig) ]

    Gene ID: 780403, updated on 2-Oct-2018

    Summary

    Gene symbol
    LRRK2
    Gene description
    leucine rich repeat kinase 2
    See related
    Ensembl:ENSSSCG00000000784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in spleen (RPKM 12.4), lung (RPKM 9.3) and 7 other tissues See more
    Orthologs

    Genomic context

    See LRRK2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (71800337..71945828)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (74510979..74653410)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 13 Neighboring gene uncharacterized LOC102165502 Neighboring gene mucin 19, oligomeric Neighboring gene POU domain, class 5, transcription factor 1 pseudogene Neighboring gene contactin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...

    General protein information

    Preferred Names
    leucine-rich repeat serine/threonine-protein kinase 2
    Names
    LRRK2/Dardarin
    NP_001106908.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113437.2NP_001106908.2  leucine-rich repeat serine/threonine-protein kinase 2

      Status: VALIDATED

      Source sequence(s)
      CU695191, EU019992
      UniProtKB/TrEMBL
      A9XXE0
      Related
      ENSSSCP00000000832.3, ENSSSCT00000000849.3
      Conserved Domains (5) summary
      cd09914
      Location:13331506
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      cd14068
      Location:18832134
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10121035
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:15261739
      COR; C-terminal of Roc, COR, domain
      cl26793
      Location:9811284
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      71800337..71945828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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