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    TPO thyroid peroxidase [ Gallus gallus (chicken) ]

    Gene ID: 776120, updated on 13-Apr-2026
    Symbol
    TPOprovided by CGNC
    Full Name
    thyroid peroxidaseprovided by CGNC
    Primary source
    CGNC:12251
    See related
    Ensembl:ENSGALG00010002300
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See TPO in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (92424909..92473953)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (92236771..92277100)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532072 Neighboring gene syntrophin gamma 2 Neighboring gene uncharacterized LOC112532071 Neighboring gene U1 spliceosomal RNA Neighboring gene peroxidasin

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Reproductive hormones, hepatic deiodinase messenger ribonucleic acid, and vasoactive intestinal polypeptide-immunoreactive cells in hypothalamus in the heat stress-induced or chemically induced hypothyroid laying hen. Elnagar SA, et al. Poult Sci, 2010 Sep. PMID 20709987
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effects of heat stress and hypothyroidism on reproductive hormones and hepatic iodide peroxidase in hens are reported.
      Title: Reproductive hormones, hepatic deiodinase messenger ribonucleic acid, and vasoactive intestinal polypeptide-immunoreactive cells in hypothalamus in the heat stress-induced or chemically induced hypothyroid laying hen.
    Submit: New GeneRIF Correction

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iodide peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    thyroid peroxidase
    XP_040523113.1
    XP_040523114.1
    XP_040523115.1
    XP_040523116.1
    XP_040523117.1
    XP_046770736.1
    XP_046795277.1

    Length

    • 863

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      92424909..92473953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046939321.1 → XP_046795277.1  thyroid peroxidase isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEQ0
      Related
      ENSGALP00010003097.1, ENSGALT00010005249.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      92236771..92277100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040667181.2 → XP_040523115.1  thyroid peroxidase isoform X2

      UniProtKB/TrEMBL
      A0A8V0X515
      Conserved Domains (3) summary
      cd00033
      Location:740 → 793
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:166 → 732
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:794 → 837
      EGF_CA; Calcium-binding EGF-like domain

    2. XM_040667179.2 → XP_040523113.1  thyroid peroxidase isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEQ0
      Conserved Domains (3) summary
      cd00033
      Location:757 → 810
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:183 → 749
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:811 → 854
      EGF_CA; Calcium-binding EGF-like domain

    3. XM_040667183.2 → XP_040523117.1  thyroid peroxidase isoform X3

      UniProtKB/TrEMBL
      A0A8V0XEQ0
      Conserved Domains (2) summary
      cd09825
      Location:183 → 749
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:754 → 797
      EGF_CA; Calcium-binding EGF-like domain

    4. XM_046914780.1 → XP_046770736.1  thyroid peroxidase isoform X4

      UniProtKB/TrEMBL
      A0A8V0X515

    5. XM_040667180.2 → XP_040523114.1  thyroid peroxidase isoform X1

      UniProtKB/TrEMBL
      A0A8V0XEQ0
      Conserved Domains (3) summary
      cd00033
      Location:757 → 810
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:183 → 749
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:811 → 854
      EGF_CA; Calcium-binding EGF-like domain

    6. XM_040667182.2 → XP_040523116.1  thyroid peroxidase isoform X2

      UniProtKB/TrEMBL
      A0A8V0X515
      Conserved Domains (3) summary
      cd00033
      Location:740 → 793
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:166 → 732
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:794 → 837
      EGF_CA; Calcium-binding EGF-like domain
    Nucleotide Protein
    Heading Accession and Version

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