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    ZNF213 zinc finger protein 213 [ Homo sapiens (human) ]

    Gene ID: 7760, updated on 11-Jul-2021

    Summary

    Official Symbol
    ZNF213provided by HGNC
    Official Full Name
    zinc finger protein 213provided by HGNC
    Primary source
    HGNC:HGNC:13005
    See related
    Ensembl:ENSG00000085644 MIM:608387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CR53; ZSCAN53; ZKSCAN21
    Summary
    C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]
    Expression
    Broad expression in testis (RPKM 12.1), ovary (RPKM 4.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF213 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3135029..3142804)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3185030..3192805)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ZNF205 antisense RNA 1 Neighboring gene zinc finger protein 205 Neighboring gene ZNF213 antisense RNA 1 (head to head) Neighboring gene caspase 16, pseudogene Neighboring gene tRNA-Arg (anticodon CCG) 1-3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 213
    Names
    putative transcription factor CR53
    zinc finger protein with KRAB and SCAN domains 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134655.2NP_001128127.1  zinc finger protein 213

      See identical proteins and their annotated locations for NP_001128127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the first exon, hence has a different 5' UTR compared to variant 1. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC108134, AK289834, AK291789, BC080572, BM974318, DA115503
      Consensus CDS
      CCDS10495.1
      UniProtKB/Swiss-Prot
      O14771
      UniProtKB/TrEMBL
      A0A0S2Z4L6
      Related
      ENSP00000459177.1, ENST00000576416.5
      Conserved Domains (4) summary
      smart00431
      Location:41145
      SCAN; leucine rich region
      cd07765
      Location:202237
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:315451
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319339
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_004220.3NP_004211.1  zinc finger protein 213

      See identical proteins and their annotated locations for NP_004211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more predominant transcript. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC108134, AK291789, BC080572, BM974318, DA811482
      Consensus CDS
      CCDS10495.1
      UniProtKB/Swiss-Prot
      O14771
      UniProtKB/TrEMBL
      A0A0S2Z4L6
      Related
      ENSP00000380087.3, ENST00000396878.8
      Conserved Domains (4) summary
      smart00431
      Location:41145
      SCAN; leucine rich region
      cd07765
      Location:202237
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:315451
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319339
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_104432.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compare to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC108134, AK055337, BC116445, DA811482
      Related
      ENST00000576863.1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      3135029..3142804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522652.3XP_011520954.1  zinc finger protein 213 isoform X1

      Conserved Domains (3) summary
      smart00431
      Location:41145
      SCAN; leucine rich region
      cd07765
      Location:202237
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      pfam02023
      Location:41127
      SCAN; SCAN domain
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