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    POLY polyprotein [ Zika virus ]

    Gene ID: 7751225, updated on 5-Jun-2026
    Gene symbol
    POLY
    Gene description
    polyprotein
    Locus tag
    ZIKV_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Zika virus (strain: MR 766, nat-host: sentinel monkey)
    Lineage
    Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Orthoflavivirus; Euflavivirus; Orthoflavivirus zikaense
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    Try the new Transcripts and proteins table
    Sequence:
    NC_012532.1 (107..10366)

    NC_012532.1Genomic Context describing neighboring genes

    Genomic Sequence:
    NC_012532.1

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells. Ng IHW, et al. ACS Infect Dis, 2019 Jun 14. PMID 30848123
    2. Structure of the immature Zika virus at 9 Å resolution. Prasad VM, et al. Nat Struct Mol Biol, 2017 Feb. PMID 28067914, Free PMC Article
    3. Nuclear localization of Zika virus NS5 contributes to suppression of type I interferon production and response. Zhao Z, et al. J Gen Virol, 2021 Mar. PMID 31859616, Free PMC Article
    4. The Envelope Residues E152/156/158 of Zika Virus Influence the Early Stages of Virus Infection in Human Cells. Bos S, et al. Cells, 2019 Nov 15. PMID 31731738, Free PMC Article
    5. Zika Virus NS2A-Mediated Virion Assembly. Zhang X, et al. mBio, 2019 Oct 29. PMID 31662457, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors.
      Title: Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors.
    2. Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection.
      Title: Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection.
    3. Investigating the conformational dynamics of Zika virus NS4B protein.
      Title: Investigating the conformational dynamics of Zika virus NS4B protein.
    4. Multiple Salivary Proteins from Aedes aegypti Mosquito Bind to the Zika Virus Envelope Protein.
      Title: Multiple Salivary Proteins from Aedes aegypti Mosquito Bind to the Zika Virus Envelope Protein.
    5. Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
      Title: Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
    6. Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
      Title: Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
    7. Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
      Title: Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
    8. NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling.
      Title: NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling.
    9. Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts.
      Title: Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts.
    10. Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.
      Title: Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.
    Submit: New GeneRIF Correction See all GeneRIFs (58)
    Preferred Names
    polyprotein

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_012532.1 Reference assembly

      Range
      107..10366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_002790881.1 polyprotein

      See identical proteins and their annotated locations for YP_002790881.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q32ZE1
      UniProtKB/TrEMBL
      A0A142IX71, A0A1B1UX06
      Conserved Domains (16) summary
      cd12149
      Location:597 → 689
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:694 → 790
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      pfam00948
      Location:793 → 1144
      Flavi_NS1; Flavivirus non-structural Protein NS1
      pfam01002
      Location:1373 → 1498
      Flavi_NS2B; Flavivirus non-structural protein NS2B
      pfam01005
      Location:1154 → 1303
      Flavi_NS2A; Flavivirus non-structural protein NS2A
      pfam01349
      Location:2266 → 2508
      Flavi_NS4B; Flavivirus non-structural protein NS4B
      pfam01350
      Location:2121 → 2265
      Flavi_NS4A; Flavivirus non-structural protein NS4A
      pfam00949
      Location:1515 → 1665
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      cd17038
      Location:216 → 290
      Flavi_M; Flavivirus envelope glycoprotein M
      cd18806
      Location:1831 → 1973
      SF2_C_viral; C-terminal helicase domain of viral helicase
      pfam00869
      Location:292 → 588
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
      pfam00972
      Location:2768 → 3412
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01003
      Location:12 → 122
      Flavi_capsid; Flavivirus capsid protein C
      pfam01570
      Location:127 → 203
      Flavi_propep; Flavivirus polyprotein propeptide
      pfam07652
      Location:1682 → 1829
      Flavi_DEAD; Flavivirus DEAD domain
      pfam01728
      Location:2571 → 2742
      FtsJ; FtsJ-like methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32ZE1.1

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