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    Slc38a3 solute carrier family 38, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 76257, updated on 9-Sep-2018

    Summary

    Official Symbol
    Slc38a3provided by MGI
    Official Full Name
    solute carrier family 38, member 3provided by MGI
    Primary source
    MGI:MGI:1923507
    See related
    Ensembl:ENSMUSG00000010064 Vega:OTTMUSG00000050784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sn1; Nat1; mNAT; Snat3; D9Ucla2; Slc38-3; 0610012J02Rik
    Expression
    Biased expression in liver adult (RPKM 1073.0), liver E18 (RPKM 123.2) and 1 other tissue See more
    Orthologs

    Genomic context

    See Slc38a3 in Genome Data Viewer
    Location:
    9 F1; 9 58.69 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (107651154..107668968, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (107553486..107569705, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting 2 Neighboring gene guanine nucleotide binding protein, alpha transducing 1 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    L-asparagine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-asparagine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-glutamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-glutamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    L-histidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-histidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    L-alanine transport ISO
    Inferred from Sequence Orthology
    more info
     
    amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    asparagine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    asparagine transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to potassium ion starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    histidine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histidine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histidine transport ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glutamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium-coupled neutral amino acid transporter 3
    Names
    N system amino acids transporter NAT-1
    N-system amino acid transporter 1
    Na(+)-coupled neutral amino acid transporter 3
    slc38a3
    system N amino acid transporter 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199217.1NP_001186146.1  sodium-coupled neutral amino acid transporter 3

      See identical proteins and their annotated locations for NP_001186146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK002607, BC054846, CJ183778
      Consensus CDS
      CCDS23503.1
      UniProtKB/Swiss-Prot
      Q9DCP2
      Related
      ENSMUSP00000142087.1, OTTMUSP00000069222, ENSMUST00000193932.5, OTTMUST00000128713
      Conserved Domains (1) summary
      pfam01490
      Location:63492
      Aa_trans; Transmembrane amino acid transporter protein
    2. NM_001199218.1NP_001186147.1  sodium-coupled neutral amino acid transporter 3

      See identical proteins and their annotated locations for NP_001186147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC055339
      Consensus CDS
      CCDS23503.1
      UniProtKB/Swiss-Prot
      Q9DCP2
      Related
      ENSMUSP00000137561.1, OTTMUSP00000069223, ENSMUST00000177567.7, OTTMUST00000128714
      Conserved Domains (1) summary
      pfam01490
      Location:63492
      Aa_trans; Transmembrane amino acid transporter protein
    3. NM_023805.3NP_076294.2  sodium-coupled neutral amino acid transporter 3

      See identical proteins and their annotated locations for NP_076294.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054846, CJ183778
      Consensus CDS
      CCDS23503.1
      UniProtKB/Swiss-Prot
      Q9DCP2
      Related
      ENSMUSP00000010208.8, OTTMUSP00000069221, ENSMUST00000010208.13, OTTMUST00000128711
      Conserved Domains (1) summary
      pfam01490
      Location:63492
      Aa_trans; Transmembrane amino acid transporter protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      107651154..107668968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313682.1XP_017169171.1  sodium-coupled neutral amino acid transporter 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9DCP2
      Conserved Domains (1) summary
      pfam01490
      Location:63492
      Aa_trans; Transmembrane amino acid transporter protein

    RNA

    1. XR_871103.1 RNA Sequence

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