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    ZNF26 zinc finger protein 26 [ Homo sapiens (human) ]

    Gene ID: 7574, updated on 2-Oct-2018

    Summary

    Official Symbol
    ZNF26provided by HGNC
    Official Full Name
    zinc finger protein 26provided by HGNC
    Primary source
    HGNC:HGNC:13053
    See related
    Ensembl:ENSG00000198393 MIM:194537; Vega:OTTHUMG00000167936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX20; HEL-179
    Expression
    Ubiquitous expression in bone marrow (RPKM 2.0), lymph node (RPKM 1.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF26 in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (132986348..133027102)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133562934..133589154)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 Neighboring gene NANOGNB pseudogene 2 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene uncharacterized LOC107984457 Neighboring gene uncharacterized LOC101928597 Neighboring gene protein tyrosine phosphatase type IVA, member 1 pseudogene 2 Neighboring gene zinc finger protein 84

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 26 (ZNF26) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20755

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 26
    Names
    epididymis luminal protein 179
    zinc finger protein KOX20

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256279.1NP_001243208.1  zinc finger protein 26 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC073911, BM718210, BU194644, DA107937
      Conserved Domains (5) summary
      smart00349
      Location:47107
      KRAB; krueppel associated box
      COG5048
      Location:209557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:489509
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4786
      KRAB; KRAB box
      pfam13465
      Location:501526
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001256280.1NP_001243209.1  zinc finger protein 26 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC073911, BM718210, CN268178, DA107937
      Conserved Domains (5) summary
      smart00349
      Location:1454
      KRAB; krueppel associated box
      COG5048
      Location:144492
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:436461
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001330513.1NP_001317442.1  zinc finger protein 26 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      BM718210, DA022426, DA107937, DA737586, DB239332, EU668356
      Consensus CDS
      CCDS81756.1
      UniProtKB/TrEMBL
      F5H6R4, V9HW07
    4. NM_001330514.1NP_001317443.1  zinc finger protein 26 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      BM718210, DA107937, DA737586, DB232386, EU668356
      Consensus CDS
      CCDS81756.1
      UniProtKB/TrEMBL
      F5H6R4, V9HW07
    5. NM_019591.3NP_062537.2  zinc finger protein 26 isoform 2

      See identical proteins and their annotated locations for NP_062537.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC073911, BM718210, DA107937, DA737586
      Consensus CDS
      CCDS31939.1
      UniProtKB/Swiss-Prot
      P17031
      UniProtKB/TrEMBL
      V9HW07
      Related
      ENSP00000333725.5, OTTHUMP00000237381, ENST00000328654.9, OTTHUMT00000397145
      Conserved Domains (3) summary
      smart00349
      Location:1474
      KRAB; krueppel associated box
      COG5048
      Location:200512
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:456476
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      132986348..133027102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019920.1XP_016875409.1  zinc finger protein 26 isoform X1

    2. XM_017019921.1XP_016875410.1  zinc finger protein 26 isoform X2

    3. XM_017019922.1XP_016875411.1  zinc finger protein 26 isoform X3

      UniProtKB/TrEMBL
      F5H6R4
      Related
      ENSP00000437420.1, OTTHUMP00000237383, ENST00000534834.1, OTTHUMT00000397147
      Conserved Domains (5) summary
      smart00349
      Location:154
      KRAB; krueppel associated box
      COG5048
      Location:156504
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:133
      KRAB; KRAB box
      pfam13465
      Location:448473
      zf-H2C2_2; Zinc-finger double domain
    4. XM_005266183.3XP_005266240.1  zinc finger protein 26 isoform X3

      See identical proteins and their annotated locations for XP_005266240.1

      UniProtKB/TrEMBL
      F5H6R4
      Conserved Domains (5) summary
      smart00349
      Location:154
      KRAB; krueppel associated box
      COG5048
      Location:156504
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:133
      KRAB; KRAB box
      pfam13465
      Location:448473
      zf-H2C2_2; Zinc-finger double domain
    5. XM_017019923.1XP_016875412.1  zinc finger protein 26 isoform X3

      UniProtKB/TrEMBL
      F5H6R4
      Conserved Domains (5) summary
      smart00349
      Location:154
      KRAB; krueppel associated box
      COG5048
      Location:156504
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:133
      KRAB; KRAB box
      pfam13465
      Location:448473
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_001748865.1 RNA Sequence

    2. XR_001748866.2 RNA Sequence

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