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    ADAM10 ADAM metallopeptidase domain 10 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 746942, updated on 21-May-2019

    Summary

    Official Symbol
    ADAM10provided by VGNC
    Official Full Name
    ADAM metallopeptidase domain 10provided by VGNC
    Primary source
    VGNC:VGNC:1570
    Locus tag
    CK820_G0008444
    See related
    Ensembl:ENSPTRG00000007116
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See ADAM10 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 15 NC_036894.1 (37051898..37202913, complement)
    104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 15 NC_006482.4 (39412991..39564009, complement)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 15 NC_006482.3 (55942343..56093952, complement)

    Chromosome 15 - NC_036894.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104002321 Neighboring gene lipase C, hepatic type Neighboring gene uncharacterized LOC104002320 Neighboring gene small nucleolar RNA U13 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 pseudogene Neighboring gene putative heat shock protein HSP 90-beta 4 Neighboring gene small nucleolar RNA U3 Neighboring gene MINDY lysine 48 deubiquitinase 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 10
    XP_001172405.1
    XP_016783775.1
    XP_016783776.1
    XP_016783777.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036894.1 Reference Clint_PTRv2 Primary Assembly

      Range
      37051898..37202913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016928286.2XP_016783775.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X2

      Conserved Domains (3) summary
      smart00050
      Location:435514
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220428
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:48141
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_001172405.4XP_001172405.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X1

      See identical proteins and their annotated locations for XP_001172405.1

      UniProtKB/TrEMBL
      H2Q9I4
      Related
      ENSPTRP00000012167.2
      Conserved Domains (3) summary
      smart00050
      Location:466545
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:220459
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:48141
      Pep_M12B_propep; Reprolysin family propeptide
    3. XM_016928288.2XP_016783777.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X4

    4. XM_016928287.2XP_016783776.1  disintegrin and metalloproteinase domain-containing protein 10 isoform X3

      Conserved Domains (2) summary
      smart00050
      Location:392471
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:146385
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
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