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    CORO2A coronin 2A [ Homo sapiens (human) ]

    Gene ID: 7464, updated on 11-Jun-2021

    Summary

    Official Symbol
    CORO2Aprovided by HGNC
    Official Full Name
    coronin 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:2255
    See related
    Ensembl:ENSG00000106789 MIM:602159
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IR10; WDR2; CLIPINB
    Summary
    This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in small intestine (RPKM 15.5), duodenum (RPKM 14.7) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CORO2A in Genome Data Viewer
    Location:
    9q22.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (98120975..98192637, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100883257..100954919, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 918, pseudogene Neighboring gene N-acetylneuraminate synthase Neighboring gene tripartite motif containing 14 Neighboring gene Sharpr-MPRA regulatory region 7304 Neighboring gene TBC1 domain family member 2 Neighboring gene ADP ribosylation factor like GTPase 8B pseudogene Neighboring gene microRNA 6854

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686G19226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coronin-2A
    Names
    WD protein IR10
    WD repeat-containing protein 2
    WD-repeat protein 2
    coronin, actin binding protein, 2A
    coronin-like protein B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003389.3NP_003380.3  coronin-2A

      See identical proteins and their annotated locations for NP_003380.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 2. Variants 1 and 2 encode the same protein and contain the same 3' UTR.
      Source sequence(s)
      AK292788, AL137073, BM822208, BM976925
      Consensus CDS
      CCDS6735.1
      UniProtKB/Swiss-Prot
      Q92828
      UniProtKB/TrEMBL
      A0A024R150, A8K9S3
      Related
      ENSP00000343746.5, ENST00000343933.9
      Conserved Domains (2) summary
      sd00039
      Location:4080
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10518
      WD40_4; Type of WD40 repeat
    2. NM_052820.4NP_438171.1  coronin-2A

      See identical proteins and their annotated locations for NP_438171.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 1. Variants 1 and 2 encode the same protein and contain the same 3' UTR.
      Source sequence(s)
      AK292788, AL137073, BC011690, BM976925
      Consensus CDS
      CCDS6735.1
      UniProtKB/Swiss-Prot
      Q92828
      UniProtKB/TrEMBL
      A0A024R150, A8K9S3
      Related
      ENSP00000364218.4, ENST00000375077.5
      Conserved Domains (2) summary
      sd00039
      Location:4080
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10518
      WD40_4; Type of WD40 repeat

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      98120975..98192637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518986.3XP_011517288.1  coronin-2A isoform X1

      See identical proteins and their annotated locations for XP_011517288.1

      UniProtKB/Swiss-Prot
      Q92828
      UniProtKB/TrEMBL
      A0A024R150
      Conserved Domains (2) summary
      sd00039
      Location:4080
      7WD40; WD40 repeat [structural motif]
      cl25676
      Location:10518
      WD40_4; Type of WD40 repeat
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