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    Cyld CYLD lysine 63 deubiquitinase [ Mus musculus (house mouse) ]

    Gene ID: 74256, updated on 9-Jun-2019

    Summary

    Official Symbol
    Cyldprovided by MGI
    Official Full Name
    CYLD lysine 63 deubiquitinaseprovided by MGI
    Primary source
    MGI:MGI:1921506
    See related
    Ensembl:ENSMUSG00000036712
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik
    Summary
    This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 5.8), cortex adult (RPKM 5.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cyld in Genome Data Viewer
    Location:
    8; 8 C3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (88697001..88751946)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (91220927..91275844)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene sorting nexin 20 Neighboring gene nucleotide-binding oligomerization domain containing 2 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene ribosomal protein S6, pseudogene 2 Neighboring gene predicted gene, 42034

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Lys48-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Lys63-specific deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Lys63-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Lys63-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein linear deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein linear deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ripoptosome assembly involved in necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with midbody ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase CYLD
    Names
    cylindromatosis (turban tumor syndrome)
    deubiquitinating enzyme CYLD
    ubiquitin thioesterase CYLD
    ubiquitin thiolesterase CYLD
    ubiquitin-specific-processing protease CYLD
    NP_001121642.1
    NP_001121643.1
    NP_001263208.1
    NP_775545.1
    XP_006531477.1
    XP_006531478.1
    XP_006531479.1
    XP_006531480.1
    XP_006531481.1
    XP_006531482.1
    XP_006531483.1
    XP_011246825.1
    XP_011246826.1
    XP_011246827.1
    XP_017168478.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128170.2NP_001121642.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform a

      See identical proteins and their annotated locations for NP_001121642.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region compared to variant 2. It encodes isoform a which is longer than isoform b.
      Source sequence(s)
      AC138025, AC156937, AK147204
      Consensus CDS
      CCDS52633.1
      UniProtKB/Swiss-Prot
      Q80TQ2
      Related
      ENSMUSP00000147654.1, ENSMUST00000209532.1
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. NM_001128171.2NP_001121643.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform b

      See identical proteins and their annotated locations for NP_001121643.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode isoform b.
      Source sequence(s)
      AC138025, AC156937
      Consensus CDS
      CCDS22513.1
      UniProtKB/Swiss-Prot
      Q80TQ2
      Related
      ENSMUSP00000148037.1, ENSMUST00000211554.1
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. NM_001276279.1NP_001263208.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform c

      See identical proteins and their annotated locations for NP_001263208.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as short (s)-CYLD) differs in the 5' UTR and lacks several alternate exons in the coding region compared to variant 2. It encodes isoform c which is shorter than isoform b.
      Source sequence(s)
      AC138025, AC156937
      Consensus CDS
      CCDS85579.1
      UniProtKB/TrEMBL
      A0A1B0GSE5
      Related
      ENSMUSP00000147904.1, ENSMUST00000209206.1
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:407762
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304376
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    4. NM_173369.3NP_775545.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform b

      See identical proteins and their annotated locations for NP_775545.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b. Both variants 2 and 4 encode isoform b.
      Source sequence(s)
      AC138025, AC156937
      Consensus CDS
      CCDS22513.1
      UniProtKB/Swiss-Prot
      Q80TQ2
      Related
      ENSMUSP00000147426.1, ENSMUST00000209559.1
      Conserved Domains (3) summary
      smart01052
      Location:468536
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:589944
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304467
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      88697001..88751946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531419.1XP_006531482.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:410765
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307379
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. XM_006531420.1XP_006531483.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

      See identical proteins and their annotated locations for XP_006531483.1

      UniProtKB/TrEMBL
      A0A1B0GSE5
      Conserved Domains (3) summary
      smart01052
      Location:127203
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:407762
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304376
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. XM_006531416.3XP_006531479.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531479.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    4. XM_011248525.2XP_011246827.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011246827.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    5. XM_006531414.1XP_006531477.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531477.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    6. XM_006531415.1XP_006531478.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531478.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    7. XM_011248524.1XP_011246826.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011246826.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    8. XM_006531417.2XP_006531480.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531480.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    9. XM_017312989.1XP_017168478.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    10. XM_006531418.2XP_006531481.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006531481.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    11. XM_011248523.2XP_011246825.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011246825.1

      UniProtKB/Swiss-Prot
      Q80TQ2
      Conserved Domains (3) summary
      smart01052
      Location:471539
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:592947
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307470
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001128169.1: Suppressed sequence

      Description
      NM_001128169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Support Center