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    vldlr very low density lipoprotein receptor [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 733485, updated on 19-Nov-2025
    Official Symbol
    vldlrprovided by Xenbase
    Official Full Name
    very low density lipoprotein receptorprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-971958
    See related
    Ensembl:ENSXETG00000011709 AllianceGenome:Xenbase:XB-GENE-971958
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    vldlrch
    Summary
    Predicted to enable apolipoprotein binding activity. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2025]
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See vldlr in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (128058687..128099846, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (115819597..115860758, complement)

    Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene pumilio RNA binding family member 3 Neighboring gene potassium channel, voltage gated modifier subfamily V, member 2 Neighboring gene uncharacterized LOC116406561 Neighboring gene U5 spliceosomal RNA Neighboring gene U5 spliceosomal RNA

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables apolipoprotein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Preferred Names
    very low-density lipoprotein receptor
    Names
    vitellogenin receptor

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      128058687..128099846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004910790.4 → XP_004910847.1  very low-density lipoprotein receptor isoform X2

      UniProtKB/TrEMBL
      A0A6I8RJ65, A0A8J0QZY3
      Related
      ENSXETP00000081848.2, ENSXETT00000070092.2
      Conserved Domains (7) summary
      smart00192
      Location:190 → 222
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:505 → 547
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:394 → 424
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:31 → 65
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:151 → 186
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:358 → 392
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:655 → 694
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    2. XM_002934177.5 → XP_002934223.1  very low-density lipoprotein receptor isoform X1

      UniProtKB/TrEMBL
      A0A8J0QL29, F7CYF4
      Related
      ENSXETP00000025606.5, ENSXETT00000025606.5
      Conserved Domains (7) summary
      smart00192
      Location:190 → 222
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:505 → 547
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:394 → 424
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:31 → 65
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:151 → 186
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:358 → 392
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl39070
      Location:655 → 694
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    Nucleotide Protein Strain
    Heading Accession and Version

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